MBNL3

Gene Symbol MBNL3
Entrez Gene 55796
Alt Symbol CHCR, MBLX, MBLX39, MBXL
Species Human
Gene Type protein-coding
Description muscleblind-like splicing regulator 3
Other Description Cys3His CCG1-required protein|muscleblind-like 3|muscleblind-like X-linked protein|muscleblind-like protein 3
Swissprots Q6UDQ1 Q9NUK0 Q5JXP4 Q5JXN8 Q9UF37 Q9H0Z7 Q5JXN9 Q8IUR4 Q8TAF4 Q8TAD9
Accessions EAX11778 EAX11779 EAX11780 Q9NUK0 AB077698 BAB85648 AB077699 BAB85649 AF467070 AAL87670 AF491305 AAM09533 AI633721 AJ427918 CAD20869 AJ427919 CAD20870 AK002178 BAA92124 AK300248 BAG62014 AK307194 AL133625 CAB63751 AW665447 AY072692 AAL65661 AY372211 AAQ75759 BC042090 AAH42090 BC074775 AAH74775 BC074776 AAH74776 BU569439 CR627122 DA832176 DB023330 DC380677 EU446986 ABZ92515 XM_005262431 XP_005262488 XM_005262432 XP_005262489 XM_005262433 XP_005262490 XM_005262434 XP_005262491 XM_005262435 XP_005262492 XM_005262436 XP_005262493 XM_005262437 XP_005262494 XM_005262438 XP_005262495 XM_005262439 XP_005262496 XM_005262440 XP_005262497 XM_005262441 XP_005262498 XM_005262442 XP_005262499 XM_006724766 XP_006724829 XM_011531363 XP_011529665 XM_011531364 XP_011529666 NM_001170701 NP_001164172 NM_001170702 NP_001164173 NM_001170703 NP_001164174 NM_001170704 NP_001164175 NM_018388 NP_060858 NM_133486 NP_597846
Function Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction. {ECO:0000269|PubMed:12297108, ECO:0000269|PubMed:15257297}.
Subcellular Location Nucleus {ECO:0000269|PubMed:11929853}. Cytoplasm {ECO:0000269|PubMed:11929853}. Note=Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.
Tissue Specificity Highly expressed in the placenta. {ECO:0000269|PubMed:11929853}.

MBNL3 (5A11) - sc-136168 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

MBNL3 (Q-16) - sc-50092 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-MBNL3 antibody - ab198047 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue labeling MBNL3 with ab198047 at 1/30 dilution.

Anti-MBNL3 antibody - ab68759 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-MBNL3 antibody (ab68759) at 1/500 dilution + human placental lysate at 50 µgSecondaryGoat anti-mouse IgG (H&L)-HRP conjugate at 1/2500 dilution

Anti-MBNL3 antibody - ab96179 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MBNL3 antibody (ab96179) at 1/1000 dilutionLane 1 : A431 whole cell lysateLane 2 : Raji whole cell lysateLysates/proteins at 30 µg per lane.

Anti-MBNL3 antibody [EPR16337] - ab197590 from Abcam

Prices $347.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR16337
Anti-MBNL3 antibody [EPR16337] (ab197590) at 1/1000 dilution + Human placenta lysate at 10 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-MBNL3 Antibody (aa251-280, AP) - LS-C237457 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MBNL3 Antibody (aa251-280, APC) - LS-C237459 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MBNL3 Antibody (aa251-280, FITC) - LS-C237461 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MBNL3 Antibody (aa251-280, Biotin) - LS-C237460 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MBNL3 Antibody (aa251-280, Azide-free, HRP) - LS-C248777 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MBNL3 Antibody (aa251-280, PE) - LS-C237462 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MBNL3 Antibody (aa250-280) - LS-C322891 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MBNL3 Antibody (aa251-280) - LS-C164062 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
MBNL3 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The MBNL3 antibody detected the MBNL3 protein (arrow).

Anti-MBNL3 Antibody (aa1-297) - LS-C185880 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence of paraformaldehyde-fixed A431 using MBNL3 antibody at 1:200 dilution.

MBNL3 Antibody - NBP1-85635 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MBNL3 Antibody [NBP1-85635] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10. Lane 2: Hep-G2

MBNL3 Antibody - NBP1-32575 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MBNL3 Antibody - H00055796-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: MBNL3 Antibody [H00055796-B01P] - Analysis of MBNL3 expression in human placenta.

MBNL3 Polyclonal Antibody - bs-5721R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MBNL3 antibody produced in mouse - SAB1411751 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-MBNL3: <B>Cat. No. SAB1411751</B>: Antibody concentration: 1-5 μg/mL. Specific band of ~38.5 kDa using human placenta lysate.

Anti-MBNL3 antibody produced in rabbit - HPA001584 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MBNL3: <B>Cat. No. HPA001584</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human placenta tissue showing positive staining of trophoblastic cells.

ANTI-MBNL3 (CENTER) antibody produced in rabbit - SAB1304531 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-MBNL3 (Center): <B>Cat. No. SAB1304531</B>: MBNL3 Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35 μg/lane).

Anti-MBNL3 antibody produced in rabbit - SAB2700956 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-MBNL3: <B>Cat. No. SAB2700956</B>: Immunofluorescence analysis of paraformaldehyde-fixed A431, using MBNL3 antibody at 1:200 dilution.

MBNL3-Antibody-Center - AP13080c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
MBNL3 Antibody (Center) (Cat. #AP13080c) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MBNL3 antibody detected the MBNL3 protein (arrow).

MBNL3 antibody [N1C3] - GTX107366 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-MBNL3 antibody [N1C3] used in ICC/IF. GTX107366
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