| Gene Symbol |
UBXN8
|
| Entrez Gene |
7993
|
| Alt Symbol |
D8S2298E, REP8, UBXD6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UBX domain protein 8
|
| Other Description |
Reproduction/chromosome 8|UBX domain-containing protein 6|UBX domain-containing protein 8|rep-8 protein|reproduction 8 protein
|
| Swissprots |
Q7Z6F2 O00124
|
| Accessions |
EAW63437 EAW63438 EAW63439 O00124 AK296600 BAG59213 AY302140 AAP57632 BC020694 AAH20694 BI462115 BI755534 BQ019612 D83767 BAA18958 D83768 BAA18959 HQ447600 ADQ32086 XM_011544655 XP_011542957 NM_001282189 NP_001269118 NM_001282199 NP_001269128 NM_005671 NP_005662
|
| Function |
Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction. {ECO:0000269|PubMed:21949850}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:21949850}; Multi-pass membrane protein {ECO:0000269|PubMed:21949850}.
|
| Tissue Specificity |
Expressed abundantly in ovary and testis, and weakly in all other tissues tested.
|