| Gene Symbol |
EID1
|
| Entrez Gene |
23741
|
| Alt Symbol |
C15orf3, CRI1, EID-1, IRO45620, PNAS-22, PTD014, RBP21
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
EP300 interacting inhibitor of differentiation 1
|
| Other Description |
21 kDa pRb-associated protein|CREBBP/EP300 inhibitor 1|CREBBP/EP300 inhibitory protein 1|E1A-like inhibitor of differentiation 1|EP300-interacting inhibitor of differentiation 1|NB4 apoptosis related protein|Rb- and p300-binding protein EID-1|retinoblastoma protein-associated protein
|
| Swissprots |
Q8N7I4 B2RD11 Q9Y6B2 Q9BZT9
|
| Accessions |
EAW77357 Q9Y6B2 AF092135 AAD40377 AF109873 AAG35179 AF274947 AAK07524 AF349444 AAK29640 AI360508 AK098383 BAC05296 AK315365 BAG37758 AL109701 CAB52022 AL357456 CAB93108 BC007944 BC024151 BC114944 AAI14945 BC114946 AAI14947 BI550673 NM_014335 NP_055150
|
| Function |
Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms. {ECO:0000269|PubMed:11073989, ECO:0000269|PubMed:11073990}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11223246}. Cytoplasm {ECO:0000269|PubMed:11223246}. Note=May shuttle between nucleus and cytoplasm. {ECO:0000250|UniProtKB:Q9DCR4, ECO:0000269|PubMed:11223246}.
|
| Tissue Specificity |
Widely expressed. Most abundantly expressed in heart, skeletal muscle, pancreas, brain and testis. Expressed at much lower levels in placenta and peripheral blood leukocyte. Barely detectable in lung. Also weakly expressed in lung carcinoma A-549 and various leukemia cell lines. {ECO:0000269|PubMed:11073990, ECO:0000269|PubMed:11223246}.
|
![Western Blot: EID1 Overexpression Lysate (Adult Normal) [NBP2-07353] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for EID1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4863_EID1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07353-img0001.jpg)