| Gene Symbol |
DCAF8
|
| Entrez Gene |
50717
|
| Alt Symbol |
GAN2, H326, WDR42A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DDB1 and CUL4 associated factor 8
|
| Other Description |
DDB1- and CUL4-associated factor 8|WD repeat domain 42A|WD repeat-containing protein 42A
|
| Swissprots |
Q53F14 D3DVE6 Q4QQI6 Q66K50 Q5TAQ9 Q12839 Q96E00 Q68CS7
|
| Accessions |
EAW52730 EAW52731 EAW52732 Q5TAQ9 AI352273 AK022091 AK026213 AK026481 AK093176 AK223475 BAD97195 AK303188 BAH13915 AK312690 BC013107 AAH13107 BC080597 AAH80597 BC098245 BC098271 AAH98271 BC099709 AAH99709 BC099846 AAH99846 BC111063 AAI11064 BP359560 BU629460 CR749801 CAH18661 DA622120 DC296401 U06631 AAA16607 NM_015726 NP_056541 NR_028103 NR_028104 NR_028105 NR_028106
|
| Function |
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:22500989}. Cytoplasm {ECO:0000269|PubMed:22500989}. Note=It shuttles between the nucleus and the cytoplasm. Nuclear import is mediated by KPNA1 and KPNB1 under the regulation of nuclear GTPase RAN. Nuclear export to the cytoplasm is XPO1 dependent. {ECO:0000269|PubMed:22500989}.
|