MADD

Gene Symbol MADD
Entrez Gene 8567
Alt Symbol DENN, IG20, RAB3GEP
Species Human
Gene Type protein-coding
Description MAP-kinase activating death domain
Other Description MAP kinase-activating death domain protein|Rab3 GDP/GTP exchange factor|differentially expressed in normal and neoplastic cells|insulinoma glucagonoma clone 20
Swissprots Q8WXG6 Q8WZ63 Q8WXG5 A8K8S7 O15293 Q8WXG4 Q8WXG3 Q15741 Q8IWD7 B5MEE5 D3DQR4 Q15732 O15065
Accessions AAB05595 EAW67930 EAW67931 EAW67932 EAW67933 EAW67934 EAW67935 EAW67936 EAW67937 EAW67938 EAW67939 EAW67940 Q8WXG6 AB002356 BAA20814 AF440100 AAL40265 AF440101 AAL40266 AF440102 AAL40267 AF440103 AAL40268 AF440434 AAL35261 AK092919 AK093619 AK292442 BAF85131 AK308780 AU077339 BC040484 AAH40484 BE242736 DA187733 DA759613 U44953 AAD12154 U77352 AAB57735 XM_005253188 XP_005253245 XM_005253189 XP_005253246 XM_005253190 XP_005253247 XM_005253191 XP_005253248 XM_005253192 XP_005253249 XM_005253193 XP_005253250 XM_005253194 XP_005253251 XM_005253195 XP_005253252 XM_005253196 XP_005253253 XM_005253197 XP_005253254 XM_005253198 XP_005253255 XM_005253199 XP_005253256 XM_005253200 XP_005253257 XM_005253201 XP_005253258 XM_005253202 XP_005253259 XM_005253203 XP_005253260 XM_005253204 XP_005253261 XM_005253205 XP_005253262 XM_005253206 XP_005253263 XM_006718360 XP_006718423 XM_006718361 XP_006718424 XM_006718362 XP_006718425 XM_006718363 XP_006718426 XM_011520428 XP_011518730 XM_011520429 XP_011518731 XM_011520430 XP_011518732 XM_011520431 XP_011518733 XM_011520432 XP_011518734 XM_011520433 XP_011518735 XM_011520434 XP_011518736 XM_011520435 XP_011518737 XM_011520436 XP_011518738 XM_011520437 XP_011518739 XM_011520438 XP_011518740 XM_011520439 XP_011518741 XM_011520440 XP_011518742 XM_011520441 XP_011518743 XM_011520442 XP_011518744 XR_242830 XR_930922 NM_001135943 NP_001129415 NM_001135944 NP_001129416 NM_003682 NP_003673 NM_130470 NP_569826 NM_130471 NP_569827 NM_130472 NP_569828 NM_130473 NP_569829 NM_130474 NP_569830 NM_130475 NP_569831 NM_130476 NP_569832
Function Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect. {ECO:0000269|PubMed:11577081, ECO:0000269|PubMed:14716293, ECO:0000269|PubMed:14735464, ECO:0000269|PubMed:15007167, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:9115275}.
Subcellular Location Membrane {ECO:0000269|PubMed:8988362}. Cytoplasm {ECO:0000269|PubMed:8988362}.
Tissue Specificity Highly expressed in fetal brain and kidney; adult testis, ovary, brain and heart. Isoform 5 is constitutively expressed in all tissues. Isoform 7 is expressed in fetal liver and in several cancer cell lines. {ECO:0000269|PubMed:14716293, ECO:0000269|PubMed:8988362, ECO:0000269|PubMed:9796103}.

MADD (H-300) - sc-98434 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MADD (H-300): sc-98434. Western blot analysis of MADD expression in non-transfected: sc-117752 (A) and mouse MADD transfected: sc-127119 (B) 293T whole cell lysates.

MADD (P-20) - sc-79630 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MADD (P-20): sc-79630. Western blot analysis of MADD expression in NIH/3T3 (A), HEK293 (B) and KNRK (C) whole cell lysates.

Anti-DENN antibody - ab2043 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DENN antibody (ab2043) at 1/250 dilutionLane 1 : Hela whole cell lysateLane 2 : A431 whole cell lysateLane 3 : K562 whole cell lysateLane 4 : NIH3T3 whole cell lysate

Anti-DENN antibody - ab137305 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-DENN antibody (ab137305) at 1/500 dilution + HepG2 cell lysate at 30 µg

Anti-DENN antibody - ab110991 from Abcam

Prices $428.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab110991 at 1/100 dilution staining DENN in Human colon carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

Anti-DENN antibody [EPR4919] - ab134117 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4919
All lanes : Anti-DENN antibody [EPR4919] (ab134117) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : 293T cell lysateLane 3 : K562 cell lysate Lane 4 : NIH 3T3 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP conjugated antibody at 1/2000 dilution

Anti-DENN / MADD Antibody (C-Terminus) IHC-plus™ - LS-B583 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-MADD antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B583 concentration 5 ug/ml.

Anti-DENN / MADD Antibody (aa1597-1647) - LS-C285973 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human MADD by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-MADD used at a dilution of 1:100. Detection: Red-fluorescent Goat anti-Rabbit IgG-heavy and light chain cross-adsorbed Antibody DyLight 594 Conjugated (A120-601D4) used at a dilution of 1:100.

Anti-DENN / MADD Antibody (C-Terminus, clone EPR4919) - LS-C138582 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4919
IHC of paraffin-embedded human breast tissue using anti-MADD antibody.

Anti-DENN / MADD Antibody (aa1100-1150) - LS-C288896 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DENN / MADD Antibody (aa729-778) - LS-C292152 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DENN / MADD Antibody (aa751-800) - LS-C119176 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain tissue, using MADD Antibody. The picture on the right is treated with the synthesized peptide.

Anti-DENN / MADD Antibody (aa1597-1647) - LS-C288898 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human MADD by Immunohistochemistry and Immunofluorescence. Sample: FFPE sections of human breast carcinoma and colon carcinoma. Antibody: Affinity purified rabbit anti-MADD used at a dilution of 1:1000 (1 ug/ml). Detection: DAB and Red-fluorescent Goat anti-Rabbit IgG-heavy and light chain, cross-adsorbed Antibody DyLight 594 Conjugated used at a dilution of 1:100.

MADD Antibody - NBP1-77033 from Novus Biologicals

Prices $299.00, $329.00
Sizes 50 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: MADD Antibody [NBP1-77033] - Whole cell lysates from the indicated cell lines with MADD antibody at 1:250 dilution.

Anti-MADD antibody produced in rabbit - PRS1150 from Sigma-Aldrich

Prices $347.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunocytochemistry</B><BR/>Anti-MADD: <B>Cat. No. PRS1150</B> Immunocytochemistry of MADD in human spleen tissue with MADD antibody at 10 μg/mL.

Anti-MADD antibody produced in rabbit - M5683 from Sigma-Aldrich

Prices $382.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Western blot analysis of MADD in whole cell lysates from the indicated cell lines with Anti-MADD (<B>Cat. No. M5683</B>) at 1:250 dilution.

Anti-MADD antibody produced in rabbit - HPA038568 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MADD: <B>Cat. No. HPA038568</B>: Immunohistochemical staining of human stomach, lower shows moderate cytoplasmic and membranous positivity in glandular cells.

Anti-MADD antibody produced in rabbit - SAB4503421 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MADD: <B>Cat. No. SAB4503421</B>: Immunohistochemistry analysis of paraffin-embedded human brain tissue using Anti-MADD antibody. Cells on the left were treated with the Anti-MADD antibody. Cells on the right (negative control) were treated with both Anti-MADD antibody and the synthesized immunogen peptide.

MADD antibody - GTX22043 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Anti-MADD antibody used in Western blot. GTX22043

MADD antibody - GTX73114 from GeneTex

Prices $319.00
Sizes 500 μl
Host Rabbit
Clonality Polyclonal

MADD antibody [EPR4919] - GTX63378 from GeneTex

Host Rabbit
Clonality Monoclonal
Clone EPR4919
Anti-MADD antibody [EPR4919] used in IHC (Formalin-fixed paraffin-embedded sections). GTX63378

MADD Antibody (OAAF02577) - OAAF02577 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

MADD Antibody (OAAF06592) - OAAF06592 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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