| Gene Symbol |
GLO1
|
| Entrez Gene |
2739
|
| Alt Symbol |
GLOD1, GLYI, HEL-S-74
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glyoxalase I
|
| Other Description |
S-D-lactoylglutathione methylglyoxal lyase|aldoketomutase|epididymis secretory protein Li 74|glx I|glyoxalase domain containing 1|ketone-aldehyde mutase|lactoyl glutathione lyase|lactoylglutathione lyase|methylglyoxalase
|
| Swissprots |
Q96J41 Q5TZW3 Q59EL0 Q96FC0 B2R6P7 P78375 B4DDV0 Q04760
|
| Accessions |
AAD31524 AAD38008 EAX03964 EAX03965 Q04760 AB209801 BAD93038 AK129573 AK130312 AK293345 BAG56861 AK312662 BAG35544 AL833442 BC001741 AAH01741 BC011365 AAH11365 BC015934 AAH15934 BT019987 AAV38790 BT019988 AAV38791 BU954454 D13315 BAA02572 DA342581 FJ224325 ACI46017 HQ448665 ADQ33143 KJ534846 AHW56486 L07837 AAA52565 S83285 AAB49495 NM_006708 NP_006699
|
| Function |
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Required for normal osteoclastogenesis. {ECO:0000269|PubMed:19199007, ECO:0000269|PubMed:23122816, ECO:0000269|PubMed:9705294}.
|
| Top Pathways |
Pyruvate metabolism
|
![Western Blot: GLO1 Overexpression Lysate (Adult Normal) [NBL1-11117] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GLO1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6455_GLO1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11117-img0002.jpg)