Rad50

Gene Symbol Rad50
Entrez Gene 19360
Alt Symbol Mrell, Rad50l
Species Mouse
Gene Type protein-coding
Description RAD50 homolog (S. cerevisiae)
Other Description DNA repair protein RAD50|mRad50
Swissprots P70388 Q6PEB0 Q8C2T7 Q9CU59
Accessions EDL33574 P70388 AK018001 BAB31030 AK037641 AK087982 BAC40074 AK132949 BAE21438 AK144155 BAE25735 BC002033 AAH02033 BC058180 AAH58180 BC168398 AAI68398 U66887 AAC52894 NM_009012 NP_033038
Function Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000250}. Chromosome, telomere {ECO:0000250}. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. {ECO:0000250}.
Tissue Specificity In adult, it is expressed at very low level in most tissues, except in heart, lung and aorta. Expressed at high level in testis. {ECO:0000269|PubMed:8910585}.
Top Pathways Homologous recombination, Non-homologous end-joining

Rad50 CRISPR/Cas9 KO Plasmid (m) - sc-422580 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rad50 HDR Plasmid (m) - sc-422580-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rad50 Double Nickase Plasmid (m) - sc-422580-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rad50 Double Nickase Plasmid (m2) - sc-422580-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rad50 CRISPR Activation Plasmid (m) - sc-422580-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rad50 CRISPR Activation Plasmid (m2) - sc-422580-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rad50 Lentiviral Activation Particles (m) - sc-422580-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rad50 Lentiviral Activation Particles (m2) - sc-422580-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Rad50 siRNA (m) - sc-37398 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Rad50 shRNA Plasmid (m) - sc-37398-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Rad50 shRNA (m) Lentiviral Particles - sc-37398-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU045741 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN39829 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND39829 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

shRNA set against Mouse RAD50 (NM_009012.2) - SHH388988 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Rad50(NM_009012.2) - SHR162022 from Creative biogene

Category siRNA
Species Reactivities Mouse

RAD50 miRNA 3'UTR clone - MiUTR1M-09885 from Creative biogene

Species Reactivities Mouse
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