Gene Symbol | LMF1 |
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Entrez Gene | 64788 |
Alt Symbol | C16orf26, HMFN1876, JFP11, TMEM112, TMEM112A |
Species | Human |
Gene Type | protein-coding |
Description | lipase maturation factor 1 |
Other Description | transmembrane protein 112 |
Swissprots | Q9H6G4 B3KS80 Q96S06 Q9H9K7 Q96FJ4 Q68CJ3 |
Accessions | AAK61259 CAH05577 EAW85696 EAW85697 EAW85698 EAW85699 EAW85700 Q96S06 AB075873 BAD38655 AK022743 BAB14218 AK025955 BAB15295 AK093050 BAG52642 AK125201 BAG54164 AK225065 AK225406 AK294329 BAG57601 AK294932 BAG58011 AL832177 BC010738 AAH10738 BC014196 BC028099 AAH28099 BC036550 BC047239 BC070105 BC081535 BC098409 BC156645 AAI56646 BM017667 CA427159 CK300754 DA200865 HG507571 HG507572 HG507573 HG507574 HG507575 HG507576 HG507577 LK938174 XM_006720926 XP_006720989 XM_006720928 XP_006720991 XM_006720929 XP_006720992 XM_011522614 XP_011520916 XM_011522615 XP_011520917 XM_011522616 XP_011520918 XM_011522617 XP_011520919 XM_011522618 XP_011520920 XR_429646 XR_932903 XR_932904 NM_022773 NP_073610 NR_033645 NR_033646 NR_036442 |
Function | Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL. {ECO:0000250, ECO:0000269|PubMed:24909692}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:19783858, ECO:0000269|PubMed:24909692}; Multi- pass membrane protein {ECO:0000269|PubMed:19783858, ECO:0000269|PubMed:24909692}. |
Lmf1 CRISPR/Cas9 KO Plasmid (h) - sc-408949 from Santa Cruz Biotechnology
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Lmf1 HDR Plasmid (h) - sc-408949-HDR from Santa Cruz Biotechnology
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Lmf1 Double Nickase Plasmid (h) - sc-408949-NIC from Santa Cruz Biotechnology
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Lmf1 Double Nickase Plasmid (h2) - sc-408949-NIC-2 from Santa Cruz Biotechnology
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Lmf1 CRISPR Activation Plasmid (h) - sc-408949-ACT from Santa Cruz Biotechnology
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Lmf1 CRISPR Activation Plasmid (h2) - sc-408949-ACT-2 from Santa Cruz Biotechnology
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Lmf1 Lentiviral Activation Particles (h) - sc-408949-LAC from Santa Cruz Biotechnology
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Lmf1 Lentiviral Activation Particles (h2) - sc-408949-LAC-2 from Santa Cruz Biotechnology
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Lmf1 siRNA (h) - sc-93070 from Santa Cruz Biotechnology
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Lmf1 shRNA Plasmid (h) - sc-93070-SH from Santa Cruz Biotechnology
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Lmf1 shRNA (h) Lentiviral Particles - sc-93070-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU031391 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11768 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11768 from Sigma-Aldrich
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LMF1 siRNA (Human) - CRJ2093 from Cohesion Biosciences
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shRNA set against Human LMF1 (NM_022773.2) - SHH330967 from Creative biogene
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shRNA set against Human TMEM112(NM_022773.2) - SHL076116 from Creative biogene
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Human LMF1 siRNA - orb272594 from Biorbyt
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LMF1 shRNA Plasmid (Human) - CHJ2093 from Cohesion Biosciences
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LMF1 miRNA 3'UTR clone - MiUTR1H-10480 from Creative biogene
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