| Gene Symbol |
VPS52
|
| Entrez Gene |
6293
|
| Alt Symbol |
ARE1, SAC2, SACM2L, dJ1033B10.5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
vacuolar protein sorting 52 homolog (S. cerevisiae)
|
| Other Description |
SAC2 suppressor of actin mutations 2-like protein|vacuolar protein sorting-associated protein 52 homolog
|
| Swissprots |
Q5SQW1 Q5JPA0 Q9NPT5 Q8IUN6 B4DNI9 A2BF38 Q53GR4 B0UZZ4 Q8N1B4
|
| Accessions |
CAA11260 CAI95618 CAI95619 EAX03686 EAX03687 EAX03688 EAX03689 EAX03690 EAX03691 EAX03692 EAX03693 Q8N1B4 AJ006026 CAA06821 AK001725 BAG50969 AK093057 AK222867 BAD96587 AK297935 BAG60251 AK299563 BAG61506 AK300308 BAG62061 AK300430 BAG62156 AK304080 BAG64987 AL390171 CAB99099 AL559461 AW150166 AX775737 CAE11568 BC032108 AAH32108 BC040114 AAH40114 BQ022405 BU167150 DC395438 DC400338 XM_011514797 XP_011513099 XM_011514798 XP_011513100 XM_011514799 XP_011513101 XM_011514800 XP_011513102 XM_011547270 XP_011545572 XM_011547271 XP_011545573 XM_011547272 XP_011545574 XM_011547273 XP_011545575 XM_011547673 XP_011545975 XM_011547674 XP_011545976 XM_011547675 XP_011545977 XM_011547676 XP_011545978 XM_011548072 XP_011546374 XM_011548073 XP_011546375 XM_011548074 XP_011546376 XM_011548075 XP_011546377 XM_011548261 XP_011546563 XM_011548262 XP_011546564 XM_011548263 XP_011546565 XM_011548264 XP_011546566 XM_011548456 XP_011546758 XM_011548457 XP_011546759 XM_011548458 XP_011546760 XM_011548459 XP_011546761 NM_001289174 NP_001276103 NM_001289175 NP_001276104 NM_001289176 NP_001276105 NM_022553 NP_072047
|
| Function |
May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. {ECO:0000269|PubMed:15878329, ECO:0000269|PubMed:18367545}.
|
| Subcellular Location |
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
|