| Gene Symbol |
OLFML3
|
| Entrez Gene |
56944
|
| Alt Symbol |
HNOEL-iso, OLF44
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
olfactomedin-like 3
|
| Other Description |
olfactomedin-like protein 3
|
| Swissprots |
Q8NBJ2 Q53HV9 Q53FR1 Q69AX9 Q5SQL6 Q9NRN5
|
| Accessions |
CAI72067 CAI72151 EAW56594 EAW56595 Q9NRN5 AF201945 AAF86881 AI559543 AK075353 BAC11564 AK075369 AK075479 BAC11644 AK075544 BAC11687 AK092766 AK222471 BAD96191 AK223221 BAD96941 AK297902 BAG60222 AY358954 AAQ89313 AY464015 AAR88262 BC009920 AAH09920 BP201458 DQ892781 ABM83707 DQ896028 ABM87027 KC237062 AGF36554 NM_001286352 NP_001273281 NM_001286353 NP_001273282 NM_020190 NP_064575
|
| Function |
Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes. {ECO:0000250, ECO:0000269|PubMed:15280020}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:15280020}.
|
| Tissue Specificity |
Abundant in placenta, moderate in liver and heart, whereas fairly weak in other tissues examined. On term placenta, mainly localized extracellularly surrounding the syncytiotrophoblastic cells and very rarely expressed in the maternal decidua layer. {ECO:0000269|PubMed:15280020}.
|
![Western Blot: OLFML3 Overexpression Lysate (Adult Normal) [NBL1-13931] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for OLFML3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10082_OLFML3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13931-img0002.jpg)