Gene Symbol | NOSTRIN |
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Entrez Gene | 115677 |
Alt Symbol | DaIP2 |
Species | Human |
Gene Type | protein-coding |
Description | nitric oxide synthase trafficking |
Other Description | BM247 homolog|ENOS traffic inducer|eNOS-trafficking inducer|endothelial nitric oxide synthase traffic inducer|nitric oxide synthase traffic inducer|nitric oxide synthase trafficker|nostrin|ortholog of mouse disabled 2 interacting proein 2 |
Swissprots | Q53S62 Q27HG3 A8K2I9 B3KSF5 E7EPT9 Q8IVI9 Q96CJ9 |
Accessions | AAX93055 AAY24097 EAX11292 EAX11293 EAX11294 EAX11295 Q8IVI9 AJ532842 CAD58724 AK002203 BAE46614 AK093444 BAG52717 AK123698 AK290254 BAF82943 BC014189 AAH14189 BC093072 AAH93072 BF114987 BP334580 BQ899074 DQ402497 ABD62889 DQ892671 ABM83597 DQ896126 ABM87125 DW437437 XM_005246270 XP_005246327 XM_006712233 XP_006712296 XM_011510540 XP_011508842 XM_011510541 XP_011508843 XM_011510542 XP_011508844 XM_011510543 XP_011508845 XM_011510544 XP_011508846 XR_427064 XR_922836 NM_001039724 NP_001034813 NM_001171631 NP_001165102 NM_001171632 NP_001165103 NM_052946 NP_443178 |
Function | Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. {ECO:0000269|PubMed:12446846, ECO:0000269|PubMed:16234328, ECO:0000269|PubMed:16807357}. |
Subcellular Location | Isoform 1: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Note=Enriched in selected actin structures. |
Tissue Specificity | Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over- expressed in placenta from women with pre-eclampsia (at protein level). {ECO:0000269|PubMed:12446846, ECO:0000269|PubMed:15847871}. |
NOSTRIN CRISPR/Cas9 KO Plasmid (h) - sc-416730 from Santa Cruz Biotechnology
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NOSTRIN HDR Plasmid (h) - sc-416730-HDR from Santa Cruz Biotechnology
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NOSTRIN Double Nickase Plasmid (h) - sc-416730-NIC from Santa Cruz Biotechnology
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NOSTRIN Double Nickase Plasmid (h2) - sc-416730-NIC-2 from Santa Cruz Biotechnology
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NOSTRIN CRISPR Activation Plasmid (h) - sc-416730-ACT from Santa Cruz Biotechnology
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NOSTRIN CRISPR Activation Plasmid (h2) - sc-416730-ACT-2 from Santa Cruz Biotechnology
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NOSTRIN Lentiviral Activation Particles (h) - sc-416730-LAC from Santa Cruz Biotechnology
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NOSTRIN Lentiviral Activation Particles (h2) - sc-416730-LAC-2 from Santa Cruz Biotechnology
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NOSTRIN siRNA (h) - sc-72295 from Santa Cruz Biotechnology
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NOSTRIN shRNA Plasmid (h) - sc-72295-SH from Santa Cruz Biotechnology
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NOSTRIN shRNA (h) Lentiviral Particles - sc-72295-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU075551 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15419 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15419 from Sigma-Aldrich
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NOSTRIN siRNA (Human) - CRJ4458 from Cohesion Biosciences
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shRNA set against Human NOS (NM_052946.3) - SHH353732 from Creative biogene
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Human NOSTRIN siRNA - orb274959 from Biorbyt
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NOSTRIN shRNA Plasmid (Human) - CHJ4458 from Cohesion Biosciences
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NOSTRIN miRNA 3'UTR clone - MiUTR3H-09268 from Creative biogene
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NOSTRIN miRNA 3'UTR clone - MiUTR3H-09269 from Creative biogene
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