| Gene Symbol |
APC
|
| Entrez Gene |
324
|
| Alt Symbol |
BTPS2, DP2, DP2.5, DP3, GS, PPP1R46
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adenomatous polyposis coli
|
| Other Description |
adenomatosis polyposis coli tumor suppressor|adenomatous polyposis coli protein|deleted in polyposis 2.5|protein phosphatase 1, regulatory subunit 46
|
| Swissprots |
Q15162 P25054 Q93042 Q15163 D3DT03
|
| Accessions |
AAB21145 AAT81590 AAW82777 AAX07544 AAX07546 ABL85064 ABL98125 ABL98126 ABQ09217 ABQ09218 ABQ09219 ABQ09220 ABQ57358 ABQ57359 ABQ57360 ABQ57361 ACD11098 ACD11100 P25054 AB210001 BAE06083 AF038181 AI492038 AK289567 BAF82256 AK294544 BAH11802 AK309033 BC034955 BC056268 AAH56268 BC111462 AAI11463 BC111591 AAI11592 BC111930 AAI11931 BE047584 BF112110 BG548363 BM271918 BM713901 BM975470 BP230350 CA313732 DA777787 DA795663 DQ317525 ABC41553 DQ320123 M73548 AAA60353 M74088 AAA03586 S56365 AAD14918 S67787 AAD13997 S67788 AAD13998 S67789 AAD13999 NM_000038 NP_000029 NM_001127510 NP_001120982 NM_001127511 NP_001120983
|
| Function |
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.
|
| Subcellular Location |
Cell junction, adherens junction. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle membrane. Cytoplasm. Cell membrane. Note=Associated with the microtubule network at the growing distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.
|
| Tissue Specificity |
Expressed in a variety of tissues.
|
| Top Pathways |
Wnt signaling pathway, HTLV-I infection, Endometrial cancer, Colorectal cancer, Hippo signaling pathway
|
![Western Blot: APC Overexpression Lysate (Adult Normal) [NBP2-09451] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for APC.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/24554_APC%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-09451-img0001.jpg)