Gene Symbol | DPM1 |
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Entrez Gene | 8813 |
Alt Symbol | CDGIE, MPDS |
Species | Human |
Gene Type | protein-coding |
Description | dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit |
Other Description | DPM synthase complex, catalytic subunit|DPM synthase subunit 1|MPD synthase subunit 1|dolichol monophosphate mannose synthase|dolichol-phosphate mannose synthase subunit 1|dolichol-phosphate mannosyltransferase subunit 1|dolichyl-phosphate beta-D-mannosyltransferase subunit 1|mannose-P-dolichol synthase subunit 1 |
Swissprots | Q6IB78 O15157 O60762 Q96HK0 |
Accessions | BAA25647 EAW75607 EAW75608 EAW75609 O60762 AF007875 AAC98797 AK289569 BAF82258 BC007073 AAH07073 BC008427 BC008466 AAH08466 BC016322 AAH16322 CR456926 CAG33207 D86198 BAA25646 HQ447146 ADQ31633 XM_005260600 XP_005260657 XM_005260601 XP_005260658 XM_011529093 XP_011527395 XM_011529094 XP_011527396 XR_244156 NM_003859 NP_003850 |
Function | Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O- mannosylation of proteins; catalytic subunit of the dolichol- phosphate mannose (DPM) synthase complex. |
Subcellular Location | Endoplasmic reticulum. |
Top Pathways | N-Glycan biosynthesis |
DPM1 CRISPR/Cas9 KO Plasmid (h) - sc-407533 from Santa Cruz Biotechnology
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DPM1 HDR Plasmid (h) - sc-407533-HDR from Santa Cruz Biotechnology
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DPM1 Double Nickase Plasmid (h) - sc-407533-NIC from Santa Cruz Biotechnology
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DPM1 Double Nickase Plasmid (h2) - sc-407533-NIC-2 from Santa Cruz Biotechnology
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DPM1 CRISPR Activation Plasmid (h) - sc-407533-ACT from Santa Cruz Biotechnology
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DPM1 CRISPR Activation Plasmid (h2) - sc-407533-ACT-2 from Santa Cruz Biotechnology
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DPM1 Lentiviral Activation Particles (h) - sc-407533-LAC from Santa Cruz Biotechnology
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DPM1 Lentiviral Activation Particles (h2) - sc-407533-LAC-2 from Santa Cruz Biotechnology
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DPM1 siRNA (h) - sc-41509 from Santa Cruz Biotechnology
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DPM1 shRNA Plasmid (h) - sc-41509-SH from Santa Cruz Biotechnology
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DPM1 shRNA (h) Lentiviral Particles - sc-41509-V from Santa Cruz Biotechnology
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DPM1 RNAi - H00008813-R01 from Novus Biologicals
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MISSION® esiRNA - EHU036421 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7455 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7455 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02171 from Sigma-Aldrich
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DPM1 siRNA (Human) - CRH5811 from Cohesion Biosciences
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DPM1 - MBS8222394 from MyBioSource
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shRNA set against Human DPM1 (NM_003859.1) - SHH280605 from Creative biogene
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shRNA set against Human DPM1(NM_003859.1) - SHG209035 from Creative biogene
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DPM1 shRNA Plasmid (Human) - CHH5811 from Cohesion Biosciences
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DPM1 miRNA 3'UTR clone - MiUTR1H-02970 from Creative biogene
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