CYP2D6

Gene Symbol	CYP2D6
Entrez Gene	1565
Alt Symbol	CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1
Species	Human
Gene Type	protein-coding
Description	cytochrome P450, family 2, subfamily D, polypeptide 6
Other Description	cytochrome P450 2D6|cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2|cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2|cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2|cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2|cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6|cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1|cytochrome P450-DB1|debrisoquine 4-hydroxylase|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
Swissprots	Q6B012 Q2XND6 Q6NXU8 P10635 Q2XND7 Q2XNE0 Q16752
Accessions	AAA35737 AAA53500 AAS55001 ABB01370 ABB01371 ABB01372 ABB01373 ABB77895 ABB77896 ABB77897 ABB77898 ABB77899 ABB77900 ABB77901 ABB77902 ABB77903 ABB77904 ABB77905 ABB77906 ABB77907 ABB77908 ABB77909 ACB41742 ACB41743 ACB41744 ACY39277 ADB78784 ADF36205 ADF36206 ADF36207 ADF36208 ADF36209 ADF36210 ADF36211 ADF36212 ADF36213 ADF36214 ADF36215 ADF36216 ADF36217 ADF36218 ADF36219 ADF36220 ADF36221 ADF36222 ADF36223 ADF36224 ADF36225 ADF36226 ADF36227 ADF36228 ADF36229 ADF36230 ADF36231 ADF36232 ADF36233 ADF36234 ADF36235 ADF36236 ADF36237 ADF36238 ADF36239 ADF36240 ADF36241 ADF36242 ADF36243 ADF36244 ADF36245 ADF36246 ADF36247 ADF36248 ADF36249 ADF36250 ADF36251 ADF36252 ADF36253 ADF36254 ADF36255 ADF36256 ADF36257 ADF36258 ADF36259 ADF36260 ADF36261 ADF36262 ADF36263 ADF36264 ADF36265 ADF36266 ADF36267 ADF36268 ADF36269 ADF36270 ADF36271 ADF36272 ADF36273 ADF36274 ADF36275 ADF36276 ADF36277 ADF36278 ADF36279 ADF36280 ADF36281 ADF36282 ADF36283 ADF36284 ADF36285 ADF36286 ADF36287 ADF36288 ADF36289 ADF36290 ADF36291 ADF36292 ADF36293 ADF36294 ADF36295 ADF36296 ADF36297 ADF36298 ADF36299 ADF36300 ADF36301 ADF36302 ADF36303 ADF36304 ADF36305 ADF36306 ADF36307 ADF36308 ADF36309 ADF36310 ADF36311 ADF36312 ADF36313 ADF36314 ADF36315 ADF36316 ADF36317 ADF36318 ADF36319 ADF36320 ADF36321 ADF36322 ADF36323 ADF36324 ADF36325 ADF36326 ADF36327 ADF36328 ADF36329 ADF36330 ADF36331 ADF36332 ADF36333 ADF36334 ADF36335 ADF36336 ADF36337 ADF36338 ADF36339 ADF36340 ADF36341 ADF36342 ADF36343 ADF36344 ADF36345 ADF36346 ADF36347 ADF36348 ADF36349 ADF36350 ADF36351 ADF36352 ADF36353 ADF36354 ADF36355 ADF36356 ADF36357 ADF36358 ADF36359 ADF36360 ADF36361 ADF36362 ADF36363 ADF36364 ADF36365 ADF36366 ADF36367 ADF36368 ADF36369 ADF36370 ADF36371 ADF36372 ADF36373 ADF36374 ADF36375 ADF36376 ADF36377 ADF36378 ADF36379 ADF36380 ADF36381 ADF36382 ADF36383 ADF36384 ADF36385 ADF36386 ADF36387 ADF36388 ADF36389 ADF36390 ADF36391 ADF36392 ADF36393 ADF36394 ADF36395 ADF36396 ADF36397 ADF36398 ADF36399 ADF36400 ADF36401 ADF36402 ADF36403 ADF36404 ADF36405 ADF36406 ADF36407 ADF36408 ADF36409 ADF36410 ADF36411 ADF36412 ADF36413 ADF36414 ADF36415 ADF36416 ADF36417 ADF36418 ADF36419 ADF36420 ADF36421 ADF36422 ADF36423 ADF36424 ADF36425 ADF36426 ADF36427 ADF36428 ADF36429 ADF36430 ADF36431 ADF36432 ADF36433 ADF36434 ADF36435 ADF36436 ADF36437 ADF36438 ADF36439 ADF36440 ADF36441 ADF36442 ADF36443 ADF36444 ADF36445 ADF36446 ADF36447 ADF36448 ADF36449 ADF36450 ADF36451 ADF36452 ADF36453 ADF36454 ADF36455 ADF36456 ADF36457 ADF36458 ADF36459 ADF36460 ADF36461 ADF36462 ADF36463 ADF36464 ADF36465 ADF36466 ADF36467 ADF36468 ADF36469 ADF36470 ADF36471 ADF36472 ADF36473 ADF36474 ADF36475 ADF36476 ADF36477 ADF36478 ADF36479 ADF36480 ADF36481 ADR66993 AEU08335 AFB69499 AFC77926 AFC77927 AFC77928 AFC77929 AFX95841 AFX95842 AGF69205 AIA09568 AIA09569 AIA09570 AIA09571 EAW60492 EAW60493 P10635 AK309600 AY663390 AAU87043 BC066877 AAH66877 BC067432 AAH67432 BC075023 AAH75023 BC075024 AAH75024 BC106757 AAI06758 BC106758 AAI06759 BC126858 AAI26859 BX096000 BX422592 CB124853 CK032845 CR456430 CAG30316 CU013213 CAK54644 CU013501 CAK54943 M20403 AAA52153 X07618 X08006 CAA30807 X16866 XM_005278354 XP_005278411 XM_011529966 XP_011528268 XM_011529967 XP_011528269 XM_011529968 XP_011528270 XM_011529969 XP_011528271 XM_011529970 XP_011528272 XM_011529971 XP_011528273 XM_011529972 XP_011528274 XM_011547541 XP_011545843 XM_011547750 XP_011546052 XM_011547751 XP_011546053 XM_011548819 XP_011547121 XR_952745 NM_000106 NP_000097 NM_001025161 NP_001020332
Function	Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. {ECO:0000269|PubMed:16352597}.
Subcellular Location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Top Pathways	Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cytochrome P450 2D6 full length protein - ab73434 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human Cytochrome P450 2D6 protein fragment - ab152317 from Abcam Category Protein Source Wheat germ Species Human

CYP2D6 Antibody Blocking Peptide - LS-E3348 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Cytochrome P450 2D6 Protein - H00001565-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CYP2D6-Antibody-N-term-Blocking-Peptide - BP14520a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CYP2D6 Protein (OPPA00836) - OPPA00836 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source Sf9 Insect Cells

Human Cytochrome P450 2D6 protein - orb90066 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source Sf9 insect cells

CYP2D6 peptide - orb217180 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg

CYP2D6 Blocking Peptide - 33R-8102 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CYP2D6 Blocking Peptide - 33R-2258 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Cytochrome P450 2D6 Blocking Peptide - abx062509 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

Cytochrome P450 2D6 Blocking Peptide - abx062510 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

Cytochrome P450 2D6 Blocking Peptide - abx062511 from Abbexa Category Peptide Species Human, Monkey

Cytochrome P450 2D6 Blocking Peptide - abx062512 from Abbexa Category Peptide Species Human

Human Cytochrome P450 2D6 Protein - abx066261 from Abbexa Category Protein Source E.coli Species Human

CYP2D6 - H00001565-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CYP2D6 - H00001565-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Cytochrome P450 2D6, Human Recombinant - 228-10299-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Sf9 insect cells. Species Human

Recombinant Human CYP2D6 - 228-10299-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Sf9 insect cells. Species Human

Recombinant Human CYP2D6 - 228-10299-3 from RayBiotech Category Protein Source Sf9 insect cells. Species Human

Cytochrome P450 2D6 (CYP2D6), Human - 20-8738 from ARP American Research Products Category Protein Prices $499.00 Sizes 50 µg Source E.coli Species Human

Decorin, human - 01-1001 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source Baculovirus recombinant, expressed in Sf12 cells Species Human

CYP2D6 fusion protein - Ag12351 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

CYP2D6 fusion protein - Ag12605 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human Cytochrome P450 2D6 - BP000699-ENZ-316 from Syd Labs Category Protein Prices $160.00, $3,500.00 Sizes 20 µg, 1 mg Source Sf9 insect cells-derived. Species Human

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