| Gene Symbol | NFKBIE |
|---|---|
| Entrez Gene | 4794 |
| Alt Symbol | IKBE |
| Species | Human |
| Gene Type | protein-coding |
| Description | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon |
| Other Description | I-kappa-B-epsilon|NF-kappa-B inhibitor epsilon|NF-kappa-BIE|ikB-E|ikB-epsilon|ikappaBepsilon |
| Swissprots | Q5T9V9 O00221 |
| Accessions | AAM27002 AAV31776 EAX04262 EAX04263 EAX04264 O00221 AK130739 BAC85418 AK301360 BAH13464 BC011676 AAH11676 BC063609 AAH63609 BC166665 AAI66665 BG759212 BX367256 U91616 AAC51216 NM_004556 NP_004547 |
| Function | Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:9315679}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. |
| Tissue Specificity | Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages. |
| Top Pathways | T cell receptor signaling pathway, B cell receptor signaling pathway, Adipocytokine signaling pathway, Neurotrophin signaling pathway, Epstein-Barr virus infection |