Gene Symbol | NFKBIE |
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Entrez Gene | 4794 |
Alt Symbol | IKBE |
Species | Human |
Gene Type | protein-coding |
Description | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon |
Other Description | I-kappa-B-epsilon|NF-kappa-B inhibitor epsilon|NF-kappa-BIE|ikB-E|ikB-epsilon|ikappaBepsilon |
Swissprots | Q5T9V9 O00221 |
Accessions | AAM27002 AAV31776 EAX04262 EAX04263 EAX04264 O00221 AK130739 BAC85418 AK301360 BAH13464 BC011676 AAH11676 BC063609 AAH63609 BC166665 AAI66665 BG759212 BX367256 U91616 AAC51216 NM_004556 NP_004547 |
Function | Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:9315679}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Tissue Specificity | Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages. |
Top Pathways | T cell receptor signaling pathway, B cell receptor signaling pathway, Adipocytokine signaling pathway, Neurotrophin signaling pathway, Epstein-Barr virus infection |
IκB-ε siRNA (h) - sc-35642 from Santa Cruz Biotechnology
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IκB-ε shRNA Plasmid (h) - sc-35642-SH from Santa Cruz Biotechnology
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IκB-ε shRNA (h) Lentiviral Particles - sc-35642-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU043691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15257 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15257 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08046 from Sigma-Aldrich
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NFKBIE siRNA (Human) - CRH3181 from Cohesion Biosciences
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IkB-epsilon RNAi - H00004794-R01 from Novus Biologicals
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shRNA set against Human NFKBIE (NM_004556.2) - SHH351932 from Creative biogene
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shRNA set against Human NFKBIE(NM_004556.2) - SHR001730 from Creative biogene
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Human NFKBIE siRNA - orb263683 from Biorbyt
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NFKBIE shRNA Plasmid (Human) - CHH3181 from Cohesion Biosciences
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NFKBIE miRNA 3'UTR clone - MiUTR1H-06753 from Creative biogene
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