Gene Symbol | GPX5 |
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Entrez Gene | 2880 |
Alt Symbol | HEL-S-75p |
Species | Human |
Gene Type | protein-coding |
Description | glutathione peroxidase 5 |
Other Description | EGLP|GPx-5|GSHPx-5|epididymal androgen-related protein|epididymal secretory glutathione peroxidase|epididymis secretory sperm binding protein Li 75p|epididymis-specific glutathione peroxidase-like protein |
Swissprots | O75715 A1A4Y0 |
Accessions | AAW56939 EAX03168 EAX03169 O75715 AJ005277 CAA06463 AK093099 BAG52653 BC111375 AAI11376 BC128159 AAI28160 BC128160 AAI28161 BX103177 DB336279 FJ460514 ACS44651 XM_011514527 XP_011512829 XM_011514528 XP_011512830 XM_011514529 XP_011512831 XM_011514530 XP_011512832 XM_011547233 XP_011545535 XM_011547234 XP_011545536 XM_011547235 XP_011545537 XM_011547236 XP_011545538 NM_001509 NP_001500 NM_003996 NP_003987 |
Function | Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. |
Subcellular Location | Secreted. |
Tissue Specificity | Epididymis. |
Top Pathways | Thyroid hormone synthesis, Glutathione metabolism, Arachidonic acid metabolism |
GPx-5 CRISPR/Cas9 KO Plasmid (h) - sc-405279 from Santa Cruz Biotechnology
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GPx-5 HDR Plasmid (h) - sc-405279-HDR from Santa Cruz Biotechnology
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GPx-5 Double Nickase Plasmid (h) - sc-405279-NIC from Santa Cruz Biotechnology
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GPx-5 Double Nickase Plasmid (h2) - sc-405279-NIC-2 from Santa Cruz Biotechnology
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GPx-5 CRISPR Activation Plasmid (h) - sc-405279-ACT from Santa Cruz Biotechnology
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GPx-5 CRISPR Activation Plasmid (h2) - sc-405279-ACT-2 from Santa Cruz Biotechnology
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GPx-5 Lentiviral Activation Particles (h) - sc-405279-LAC from Santa Cruz Biotechnology
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GPx-5 Lentiviral Activation Particles (h2) - sc-405279-LAC-2 from Santa Cruz Biotechnology
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GPx-5 siRNA (h) - sc-62419 from Santa Cruz Biotechnology
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GPx-5 shRNA Plasmid (h) - sc-62419-SH from Santa Cruz Biotechnology
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GPx-5 shRNA (h) Lentiviral Particles - sc-62419-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU230321 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9649 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9649 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01369 from Sigma-Aldrich
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GPX5 siRNA (Human) - CRH1937 from Cohesion Biosciences
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GPX5 - MBS8223603 from MyBioSource
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shRNA set against Human Gpx5 (NM_001509.2) - SHH307410 from Creative biogene
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Human GPX5 siRNA - orb262439 from Biorbyt
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GPX5 shRNA Plasmid (Human) - CHH1937 from Cohesion Biosciences
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