| Gene Symbol |
Msh6
|
| Entrez Gene |
17688
|
| Alt Symbol |
AU044881, AW550279, GTBP, Gtmbp
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
mutS homolog 6 (E. coli)
|
| Other Description |
DNA mismatch repair protein Msh6|g/T mismatch-binding protein|mutS-alpha 160 kDa subunit|p160
|
| Swissprots |
O54710 P54276 Q6GTK8
|
| Accessions |
AAB88445 P54276 AK010643 BAB27085 AK088259 BAC40242 BC035274 BC051160 AAH51160 BC051634 AAH51634 CN458717 U41283 AAA83775 U42190 AAC53034 U61388 AAB39930 U61389 AAB39931 NM_010830 NP_034960
|
| Function |
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch re
|
| Subcellular Location |
Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Associates with H3K36me3 via its PWWP domain. {ECO:0000250}.
|
| Top Pathways |
Mismatch repair, Colorectal cancer
|