| Function |
Receptor for secretory phospholipase A2 (sPLA2). Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2- IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow- derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholi
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![All lanes : Anti-PLA2R antibody [CL0474] (ab188028) at 1/500 dilutionLane 1 : Vector only transfected HEK293T cell lysateLane 2 : PLA2R transfected HEK293T cell lysate with a C-terminal myc-DDK tag](http://www.bioprodhub.com/system/product_images/ab_products/2/sub_4/13022_ab188028-220656-wb.jpg)