| Gene Symbol |
PRUNE2
|
| Entrez Gene |
158471
|
| Alt Symbol |
A214N16.3, BMCC1, BNIPXL, C9orf65, KIAA0367, bA214N16.3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
prune homolog 2 (Drosophila)
|
| Other Description |
BCH motif-containing molecule at the carboxyl terminal region 1|BNIP2 motif containing molecule at the carboxyl terminal region 1|BNIP2 motif-containing molecule at the C-terminal region 1|olfaxin|protein prune homolog 2|truncated PRUNE2
|
| Swissprots |
Q6T2V6 Q5T476 Q58A63 Q8N665 O15073 B3KYC4 B4DQH8 Q5T304 Q5JUB6 Q6T2V7 Q8WUY3
|
| Accessions |
CCQ43495 EAW62581 EAW62582 EAW62583 EAW62584 EAW62585 EAW62586 EAW62587 EAW62588 EAW62594 Q8WUY3 AB002365 BAA20822 AB050197 BAD93351 AB535152 BAJ08045 AK296269 BAG58979 AK298805 BAG60940 AK299857 BAG61715 AL834213 AY439213 AAR15150 AY439214 AAR15151 BC019095 BC022571 AAH22571 BC150641 AAI50642 BQ008420 CB146736 DA410068 DC316956 DC342565 FJ808772 ACY78253 FJ808773 ACY78254 JF432723 ADZ15940 XM_005251745 XP_005251802 XM_005251746 XP_005251803 XM_005251748 XP_005251805 XM_005251750 XP_005251807 XM_005251751 XP_005251808 XM_005251752 XP_005251809 XM_005251753 XP_005251810 XM_005251754 XP_005251811 XM_006716982 XP_006717045 XM_006716983 XP_006717046 XM_006716984 XP_006717047 XM_006716985 XP_006717048 XM_006716986 XP_006717049 XM_011518323 XP_011516625 XM_011518324 XP_011516626 XM_011518325 XP_011516627 XM_011518326 XP_011516628 XM_011518327 XP_011516629 XM_011518328 XP_011516630 XR_428517 NM_138818 NM_001308047 NP_001294976 NM_001308048 NP_001294977 NM_001308049 NP_001294978 NM_001308050 NP_001294979 NM_001308051 NP_001294980 NM_015225 NP_056040 NR_131751
|
| Function |
May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16288218}.
|
| Tissue Specificity |
A high level of expression seen in the nervous system (brain, cerebellum and spinal cord) as well as adrenal gland. Expressed at high levels in noneuroblastoma, rhabdomyosarcoma, melanoma and some osteosarcoma cell lines, whereas at only low levels in cancer cell lines of liver, breast, thyroid and colon. Expression is significantly higher in favorable tumors than aggressive ones. {ECO:0000269|PubMed:16288218}.
|