| Gene Symbol |
SEC16A
|
| Entrez Gene |
9919
|
| Alt Symbol |
KIAA0310, SEC16L, p250
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SEC16 homolog A (S. cerevisiae)
|
| Other Description |
protein SEC16 homolog A|protein transport protein Sec16A
|
| Swissprots |
Q8N347 Q96HP1 O15027 Q5SXP1 A1YCA4 Q5SXP0 Q4G0D7
|
| Accessions |
O15027 AB002308 BAA20769 AB593115 BAJ84055 AB621812 BAK64148 AK074565 BAC11063 AK094041 AK094756 BAC04415 AK124843 AK126215 AK129634 AK130247 BAC85312 AK301371 BAG62913 AK302210 BAG63568 AK310722 AK316194 BAH14565 BC001404 AAH01404 BC008332 AAH08332 BC016873 AAH16873 BC028183 AAH28183 BC040710 BC051290 BC070488 BC098454 AAH98454 BC125018 AAI25019 BC125019 AAI25020 BM975558 DQ593401 DQ595727 DQ903855 ABI78944 XM_005266134 XP_005266191 XM_011519246 XP_011517548 XM_011519247 XP_011517549 XM_011519248 XP_011517550 XM_011519249 XP_011517551 XM_011519250 XP_011517552 XM_011519251 XP_011517553 XM_011519252 XP_011517554 XM_011519253 XP_011517555 XM_011519254 XP_011517556 XM_011519255 XP_011517557 XM_011519256 XP_011517558 XM_011519257 XP_011517559 XM_011519258 XP_011517560 XM_011519259 XP_011517561 XM_011519260 XP_011517562 XM_011519261 XP_011517563 XM_011519262 XP_011517564 XM_011519263 XP_011517565 XM_011519264 XP_011517566 XR_929881 NM_001276418 NP_001263347 NM_014866 NP_055681
|
| Function |
Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for normal transitional endoplasmic reticulum (tER) organization. {ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=SAR1A activity is required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation.
|
| Tissue Specificity |
Ubiquitous. Expressed at higher levels in the pancreas. {ECO:0000269|PubMed:17192411}.
|