| Gene Symbol | Got1 |
|---|---|
| Entrez Gene | 14718 |
| Alt Symbol | AI789014, Got-1, cAspAT, cCAT |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | glutamic-oxaloacetic transaminase 1, soluble |
| Other Description | aspartate aminotransferase, cytoplasmic|cysteine aminotransferase, cytoplasmic|cysteine transaminase, cytoplasmic|cytosolic aspartate aminotransferase|glutamate oxaloacetate transaminase 1, soluble|transaminase A |
| Swissprots | Q3UJH8 P05201 |
| Accessions | CAA30275 EDL41904 P05201 AK146445 BAE27177 AK147807 AK147934 AK186873 AK192547 AK195432 AK203412 AK212371 AV574373 BC002057 AAH02057 BY441762 CK334037 J02623 AAA37263 XR_386441 NM_010324 NP_034454 |
| Function | Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Expressed in neurons of the retina. Localizes to the inner and outer plexiform layers, the inner and outer nuclear layer and the outer segments of photoreceptors. {ECO:0000269|PubMed:21937432}. |
| Top Pathways | Cysteine and methionine metabolism, Alanine, aspartate and glutamate metabolism, Phenylalanine metabolism, Biosynthesis of amino acids, Tyrosine metabolism |