| Gene Symbol |
Got1
|
| Entrez Gene |
14718
|
| Alt Symbol |
AI789014, Got-1, cAspAT, cCAT
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
glutamic-oxaloacetic transaminase 1, soluble
|
| Other Description |
aspartate aminotransferase, cytoplasmic|cysteine aminotransferase, cytoplasmic|cysteine transaminase, cytoplasmic|cytosolic aspartate aminotransferase|glutamate oxaloacetate transaminase 1, soluble|transaminase A
|
| Swissprots |
Q3UJH8 P05201
|
| Accessions |
CAA30275 EDL41904 P05201 AK146445 BAE27177 AK147807 AK147934 AK186873 AK192547 AK195432 AK203412 AK212371 AV574373 BC002057 AAH02057 BY441762 CK334037 J02623 AAA37263 XR_386441 NM_010324 NP_034454
|
| Function |
Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Expressed in neurons of the retina. Localizes to the inner and outer plexiform layers, the inner and outer nuclear layer and the outer segments of photoreceptors. {ECO:0000269|PubMed:21937432}.
|
| Top Pathways |
Cysteine and methionine metabolism, Alanine, aspartate and glutamate metabolism, Phenylalanine metabolism, Biosynthesis of amino acids, Tyrosine metabolism
|