| Gene Symbol | RAN |
|---|---|
| Entrez Gene | 5901 |
| Alt Symbol | ARA24, Gsp1, TC4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | RAN, member RAS oncogene family |
| Other Description | GTP-binding nuclear protein Ran|GTPase Ran|OK/SW-cl.81|RanGTPase|androgen receptor-associated protein 24|guanosine triphosphatase Ran|member RAS oncogene family|ras-like protein TC4|ras-related nuclear protein |
| Swissprots | Q8NI90 A8K3Z8 Q6IPB2 P62826 |
| Accessions | AAB24940 EAW98515 EAW98516 EAW98517 P62826 AB062399 BAB93486 AF052578 AAC05840 AF054183 AAC99400 AF501887 AAM15923 AK300934 BAG62563 AK311223 AK312466 BAG35373 AK316193 BAH14564 AL357616 BC000852 BC004272 AAH04272 BC014518 AAH14518 BC014901 AAH14901 BC016654 AAH16654 BC022813 BC051908 AAH51908 BC072000 AAH72000 BT007271 AAP35935 CR450347 CAG29343 DQ892358 ABM83284 DQ895565 ABM86491 HY139187 HY336901 M31469 AAA36546 NM_001300796 NP_001287725 NM_001300797 NP_001287726 NM_006325 NP_006316 |
| Function | GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. {ECO:0000250}. |
| Subcellular Location | Nucleus. Cytoplasm. Melanosome. Note=Predominantly nuclear during interphase (By similarity). Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250}. |
| Tissue Specificity | Expressed in a variety of tissues. {ECO:0000269|PubMed:2108320}. |
| Top Pathways | RNA transport, Ribosome biogenesis in eukaryotes, HTLV-I infection, Epstein-Barr virus infection |