GSN

Gene Symbol	GSN
Entrez Gene	2934
Alt Symbol	ADF, AGEL
Species	Human
Gene Type	protein-coding
Description	gelsolin
Other Description	actin-depolymerizing factor|brevin
Swissprots	B7Z5V1 Q8WVV7 Q5T0I2 A8MUD1 B7Z373 F5H1A8 P06396 A8MYN7 A2A418
Accessions	CAA30101 CAA30102 EAW87489 EAW87490 EAW87491 P06396 AI742454 AK092797 BAG52611 AK096280 BAG53247 AK125819 BAG54252 AK295201 BAH12010 AK295572 BAH12109 AK297870 BAH12682 AK299453 BAH13037 AK300631 BAH13318 AK304629 BAH14228 AK304675 BAH14236 AK307859 AK315494 BAG37878 AL832070 CAH10407 BC017491 AAH17491 BC026033 AAH26033 BU151663 BX647999 DA294394 DA394782 DA450851 DA823796 DB170452 DB250757 DC316173 DC341948 DC370937 DC378873 DQ892187 ABM83113 EU176693 ABW03494 X04412 CAA28000 XM_005251940 XP_005251997 XM_005251943 XP_005252000 XM_005251944 XP_005252001 XM_005251945 XP_005252002 XM_006717075 XP_006717138 XM_006717079 XP_006717142 XM_011518584 XP_011516886 XM_011518585 XP_011516887 XM_011518586 XP_011516888 XM_011518587 XP_011516889 XM_011518588 XP_011516890 XM_011518589 XP_011516891 XM_011518590 XP_011516892 XM_011518591 XP_011516893 XM_011518592 XP_011516894 XM_011518593 XP_011516895 XM_011518594 XP_011516896 NM_000177 NP_000168 NM_001127662 NP_001121134 NM_001127663 NP_001121135 NM_001127664 NP_001121136 NM_001127665 NP_001121137 NM_001127666 NP_001121138 NM_001127667 NP_001121139 NM_001258029 NP_001244958 NM_001258030 NP_001244959 NM_198252 NP_937895
Function	Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. {ECO:0000269|PubMed:20393563}.
Subcellular Location	Isoform 2: Cytoplasm, cytoskeleton.
Tissue Specificity	Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.
Top Pathways	Fc gamma R-mediated phagocytosis, Viral carcinogenesis, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

SignalSilence ® Gelsolin siRNA II - 6473 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® Gelsolin siRNA I - 6469 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

Gelsolin CRISPR/Cas9 KO Plasmid (h) - sc-401005 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Gelsolin HDR Plasmid (h) - sc-401005-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Gelsolin Double Nickase Plasmid (h) - sc-401005-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Gelsolin Double Nickase Plasmid (h2) - sc-401005-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Gelsolin CRISPR Activation Plasmid (h) - sc-401005-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Gelsolin CRISPR Activation Plasmid (h2) - sc-401005-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Gelsolin Lentiviral Activation Particles (h) - sc-401005-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Gelsolin Lentiviral Activation Particles (h2) - sc-401005-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Gelsolin siRNA (h) - sc-37330 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Gelsolin shRNA Plasmid (h) - sc-37330-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Gelsolin shRNA (h) Lentiviral Particles - sc-37330-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Gelsolin/GSN RNAi - H00002934-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Gelsolin/GSN RNAi - H00002934-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU071471 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9726 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9726 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01600 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr01600

GSN siRNA (Human) - CRH1982 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

GSN - MBS8231882 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Gelsolin CRISPR/Cas9 KO Plasmid (h2) - sc-401005-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Gelsolin HDR Plasmid (h2) - sc-401005-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Human GSN siRNA - orb262484 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

GSN shRNA Plasmid (Human) - CHH1982 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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