Gene Symbol | MYBPC3 |
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Entrez Gene | 4607 |
Alt Symbol | CMD1MM, CMH4, FHC, LVNC10, MYBP-C |
Species | Human |
Gene Type | protein-coding |
Description | myosin binding protein C, cardiac |
Other Description | C-protein, cardiac muscle isoform|myosin-binding protein C, cardiac-type |
Swissprots | Q16410 Q14896 A5PL00 Q6R2F7 Q9UM53 Q9UE27 |
Accessions | AAC04620 AAR89909 ADL14489 CAA71216 EAW67927 EAW67928 EAW67929 Q14896 AJ708511 AJ708699 AK291569 BAF84258 AK297843 BAG60177 AL691822 AU140784 BC136543 AAI36544 BC136546 AAI36547 BC142685 AAI42686 BC151211 AAI51212 DA563514 EF560722 ABQ59032 EU747718 ACH92816 EU747719 ACH92817 S80778 AAB35662 S80782 AAB35663 X84075 CAA58882 XM_011520117 XP_011518419 XM_011520118 XP_011518420 NM_000256 NP_000247 |
Function | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
Top Pathways | Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy |
MYBPC3 CRISPR/Cas9 KO Plasmid (h) - sc-401409 from Santa Cruz Biotechnology
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MYBPC3 HDR Plasmid (h) - sc-401409-HDR from Santa Cruz Biotechnology
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MYBPC3 Double Nickase Plasmid (h) - sc-401409-NIC from Santa Cruz Biotechnology
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MYBPC3 Double Nickase Plasmid (h2) - sc-401409-NIC-2 from Santa Cruz Biotechnology
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MYBPC3 CRISPR Activation Plasmid (h) - sc-401409-ACT from Santa Cruz Biotechnology
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MYBPC3 CRISPR Activation Plasmid (h2) - sc-401409-ACT-2 from Santa Cruz Biotechnology
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MYBPC3 Lentiviral Activation Particles (h) - sc-401409-LAC from Santa Cruz Biotechnology
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MYBPC3 Lentiviral Activation Particles (h2) - sc-401409-LAC-2 from Santa Cruz Biotechnology
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MYBPC3 siRNA (h) - sc-61111 from Santa Cruz Biotechnology
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MYBPC3 shRNA Plasmid (h) - sc-61111-SH from Santa Cruz Biotechnology
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MYBPC3 shRNA (h) Lentiviral Particles - sc-61111-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU023971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14797 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14797 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02009 from Sigma-Aldrich
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MYBPC3 siRNA (Human) - CRH3038 from Cohesion Biosciences
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shRNA set against Human MYBPC3 (NM_000256.3) - SHH347488 from Creative biogene
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shRNA set against Human MYBPC3(NM_000256.3) - SHH210395 from Creative biogene
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Human MYBPC3 siRNA - orb263540 from Biorbyt
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MYBPC3 shRNA Plasmid (Human) - CHH3038 from Cohesion Biosciences
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MYBPC3 miRNA 3'UTR clone - MiUTR1H-06554 from Creative biogene
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