| Gene Symbol | Hmgb1 |
|---|---|
| Entrez Gene | 15289 |
| Alt Symbol | DEF, HMG-1, Hmg1, SBP-1, amphoterin, p30 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | high mobility group box 1 |
| Other Description | high mobility group protein 1|high mobility group protein B1 |
| Swissprots | P63158 |
| Accessions | CAA56631 CBF60315 CBF60321 CBF61325 CBF61331 CBF61868 CBF61874 CBF82131 CBF82146 CBU85559 CBU85565 CBU86353 CBU86359 CBU86744 CBU86750 CBV00243 CBV00249 EDL05858 P63158 AK034535 AK037928 BAC29902 AK050659 BAC34367 AK051800 BAC34773 AK082902 BAC38678 AK084841 BAC39289 AK087949 AK088347 AK134228 AK144428 AK146420 BAE27155 AK150924 BAE29962 AK157846 BAE34226 AK166007 AK206984 BC006586 AAH06586 BC008565 AAH08565 BC064790 AAH64790 BC083067 AAH83067 BC085090 AAH85090 BC091741 AAH91741 BC094030 AAH94030 BC100312 AAI00313 BC110667 AAI10668 BC111468 AAI11469 BP760493 L38477 AAA57042 U00431 AAA20508 Z11997 CAA78042 XM_006504807 XP_006504870 NM_010439 NP_034569 |
| Function | DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. {ECO:0000269|PubMed:9184213}. |
| Subcellular Location | Nucleus. Cytoplasm. Chromosome. Note=Associated with the plasma membrane of filipodia in process- growing cells, and also deposited into the substrate-attached material. |
| Top Pathways | Base excision repair |
HMG-1 CRISPR/Cas9 KO Plasmid (m) - sc-420871 from Santa Cruz Biotechnology
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HMG-1 HDR Plasmid (m) - sc-420871-HDR from Santa Cruz Biotechnology
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HMG-1 Double Nickase Plasmid (m) - sc-420871-NIC from Santa Cruz Biotechnology
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HMG-1 Double Nickase Plasmid (m2) - sc-420871-NIC-2 from Santa Cruz Biotechnology
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HMG-1 CRISPR Activation Plasmid (m) - sc-420871-ACT from Santa Cruz Biotechnology
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HMG-1 CRISPR Activation Plasmid (m2) - sc-420871-ACT-2 from Santa Cruz Biotechnology
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HMG-1 Lentiviral Activation Particles (m) - sc-420871-LAC from Santa Cruz Biotechnology
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HMG-1 Lentiviral Activation Particles (m2) - sc-420871-LAC-2 from Santa Cruz Biotechnology
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HMG-1 siRNA (m) - sc-37983 from Santa Cruz Biotechnology
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HMG-1 shRNA Plasmid (m) - sc-37983-SH from Santa Cruz Biotechnology
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HMG-1 shRNA (m) Lentiviral Particles - sc-37983-V from Santa Cruz Biotechnology
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HMG-1/2/3 siRNA (m) - sc-270031 from Santa Cruz Biotechnology
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HMG-1/2/3 shRNA Plasmid (m) - sc-270031-SH from Santa Cruz Biotechnology
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HMG-1/2/3 shRNA (m) Lentiviral Particles - sc-270031-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU210181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN33336 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33336 from Sigma-Aldrich
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HMGB1 siRNA (Mouse) - CRM1843 from Cohesion Biosciences
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HMGB1 - MBS8222378 from MyBioSource
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shRNA set against Mouse Hmgb1(NM_010439.3) - SHH125057 from Creative biogene
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HMG-1 CRISPR/Cas9 KO Plasmid (m2) - sc-420871-KO-2 from Santa Cruz Biotechnology
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HMG-1 HDR Plasmid (m2) - sc-420871-HDR-2 from Santa Cruz Biotechnology
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Mouse HMGB1 siRNA - orb281319 from Biorbyt
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HMGB1 shRNA Plasmid (Mouse) - CHM1843 from Cohesion Biosciences
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HMGB1 miRNA 3'UTR clone - MiUTR1M-05695 from Creative biogene
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