| Gene Symbol | Ifitm3 |
|---|---|
| Entrez Gene | 66141 |
| Alt Symbol | 1110004C05Rik, Cd225, Cdw217, DSPA2b, Fgls, IP15, mil-1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | interferon induced transmembrane protein 3 |
| Other Description | dispanin subfamily A member 2b|fragilis protein|ifitm-like protein 1|interferon-induced transmembrane protein 3|interferon-inducible protein 15 |
| Swissprots | Q9D8L6 Q9CQW9 |
| Accessions | EDL17977 Q9CQW9 AK003407 BAB22771 AK007916 BAB25347 AK007919 BAB25350 AK151890 BAE30774 AY082484 AAM03316 AY594690 AAT06089 BC010291 AAH10291 NM_025378 NP_079654 |
| Function | IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV) and human immunodeficiency virus type 1 (HIV-1). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. Involved in initiating germ cell competence and specification, and in th |
| Subcellular Location | Cell membrane; Single-pass type II membrane protein. Late endosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed in acinar cell. Predominantly expressed in nascent primordial germ cells, as well as in gonadal germ cells. {ECO:0000269|PubMed:12659663, ECO:0000269|PubMed:15184081}. |