| Gene Symbol |
Mre11a
|
| Entrez Gene |
17535
|
| Alt Symbol |
Mre11, Mre11b
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
meiotic recombination 11 homolog A (S. cerevisiae)
|
| Other Description |
MRE11 homolog 1|MRE11 homolog A|double-strand break repair protein MRE11A|meiotic recombination 11 homolog 1|mmMRE11A
|
| Swissprots |
Q62430 Q61216
|
| Accessions |
EDL25006 EDL25007 EDL25008 Q61216 AK041248 BAC30878 AK141214 BAE24593 AK146234 BAE27000 AK146370 BAE27119 AK161013 BAE36147 AK168180 BAE40140 AK168208 AK190567 BC065144 AAH65144 U58987 AAB04955 U60318 AAB03664 XM_006510048 XP_006510111 XM_006510049 XP_006510112 XM_006510050 XP_006510113 XM_006510051 XP_006510114 XM_006510052 XP_006510115 XM_006510053 XP_006510116 XM_006510054 XP_006510117 XR_379107 NM_018736 NP_061206
|
| Function |
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. {ECO:0000250}.
|
| Top Pathways |
Homologous recombination, Non-homologous end-joining
|