Gene Symbol | NAT8B |
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Entrez Gene | 51471 |
Alt Symbol | CML2, Hcml2, NAT8BP |
Species | Human |
Gene Type | protein-coding |
Description | N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene) |
Other Description | ATase1|N-acetyltransferase Camello 2|acetyltransferase 1|camello-like protein 2|probable N-acetyltransferase 8B|putative N-acetyltransferase 8B |
Swissprots | Q0VAD9 Q9UHF3 Q6NT18 |
Accessions | EAW99724 Q9UHF3 AF185571 AAF22299 BC069564 BC121101 BC121102 BC160071 AAI60071 BX105650 NM_016347 NP_057431 |
Function | May have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241). {ECO:0000269|PubMed:19011241, ECO:0000269|PubMed:24556617}. |
Subcellular Location | Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Enriched in the Endoplasmic reticulum-Golgi intermediate compartment. |
NAT-8B CRISPR/Cas9 KO Plasmid (h) - sc-412205 from Santa Cruz Biotechnology
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NAT-8B HDR Plasmid (h) - sc-412205-HDR from Santa Cruz Biotechnology
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NAT-8B Double Nickase Plasmid (h) - sc-412205-NIC from Santa Cruz Biotechnology
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NAT-8B Double Nickase Plasmid (h2) - sc-412205-NIC-2 from Santa Cruz Biotechnology
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NAT-8B CRISPR Activation Plasmid (h) - sc-412205-ACT from Santa Cruz Biotechnology
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NAT-8B CRISPR Activation Plasmid (h2) - sc-412205-ACT-2 from Santa Cruz Biotechnology
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NAT-8B Lentiviral Activation Particles (h) - sc-412205-LAC from Santa Cruz Biotechnology
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NAT-8B Lentiviral Activation Particles (h2) - sc-412205-LAC-2 from Santa Cruz Biotechnology
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NAT-8B siRNA (h) - sc-94680 from Santa Cruz Biotechnology
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NAT-8B shRNA Plasmid (h) - sc-94680-SH from Santa Cruz Biotechnology
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NAT-8B shRNA (h) Lentiviral Particles - sc-94680-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN14971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14971 from Sigma-Aldrich
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NAT8B siRNA (Human) - CRH9780 from Cohesion Biosciences
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shRNA set against Human NAT8B (NM_016347.2) - SHH349536 from Creative biogene
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Human NAT8B siRNA - orb270282 from Biorbyt
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NAT8B shRNA Plasmid (Human) - CHH9780 from Cohesion Biosciences
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NAT8B miRNA 3'UTR clone - MiUTR1H-06651 from Creative biogene
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