CXCR4

Gene Symbol	CXCR4
Entrez Gene	7852
Alt Symbol	CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS
Species	Human
Gene Type	protein-coding
Description	chemokine (C-X-C motif) receptor 4
Other Description	C-X-C chemokine receptor type 4|CD184 antigen|LPS-associated protein 3|SDF-1 receptor|fusin|leukocyte-derived seven transmembrane domain receptor|lipopolysaccharide-associated protein 3|neuropeptide Y receptor Y3|seven transmembrane helix receptor|seven-transmembrane-segment receptor, spleen|stromal cell-derived factor 1 receptor
Swissprots	Q9BXA0 Q9UKN2 O60835 P61073 P56438 Q53S69 P30991 B2R5N0
Accessions	AAB93982 AAC34581 AAU05775 AAY24044 BAC05813 CAA12166 CAA75034 CBG22675 CBJ06540 EAX11616 P61073 AF025375 AAB81970 AF147204 AAF00130 AF348491 AAK29630 AK129916 AK296674 BAG59271 AK309641 AK309885 AK312244 BAG35177 AY242129 AAO92296 AY826773 AAV97584 BC020968 AAH20968 BT006660 AAP35306 D10924 BAA01722 D28433 BAA05799 EU831811 ACE87329 EU831888 ACE86647 JF432649 ADZ15866 L01639 AAA16594 L06797 AAA03209 M99293 AAA16617 X71635 CAA50641 NM_001008540 NP_001008540 NM_003467 NP_003458
Function	Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. {ECO:0000269|PubMed:10074102, ECO:0000269|PubMed:10644702, ECO:0000269|PubMed:10825158
Subcellular Location	Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome. Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC).
Tissue Specificity	Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested. {ECO:0000269|PubMed:11276205}.
Top Pathways	Cytokine-cytokine receptor interaction, Axon guidance, Leukocyte transendothelial migration, Endocytosis, Intestinal immune network for IgA production

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse CXCR4 ELISA Kit (Sandwich ELISA) - LS-F6189 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 27 pg/ml Range 78.13-5000 pg/ml

Pig CXCR4 ELISA Kit (Sandwich ELISA) - LS-F6720 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.059 ng/ml Range 78.13-5000 pg/ml

Mouse/Human/Rat Phospho-CXCR4 (Ser339) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1342 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 78.13-5000 pg/ml

Human CXCR4 ELISA Kit (Sandwich ELISA) - LS-F7261 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 78.13-5000 pg/ml

Human CXCR4 ELISA Kit (Sandwich ELISA) - LS-F11258 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 78.13-5000 pg/ml

Pig CXCR4 ELISA Kit (Sandwich ELISA) - LS-F11259 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 78 Range 78.13-5000 pg/ml

Human CXCR4 ELISA Kit - abx151214 from Abbexa Category ELISA Kit Sensitivity 0.054 ng/ml Range 0.156 ng/ml - 10 ng/ml

C-X-C chemokine receptor type 4, CXCR4, Human, ELISA Kit - E2170h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Chemokine C-X-C-Motif Receptor 4 (CXCR4), Human, ELISA Kit - SEA940Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.053ng/mL Range 0.156-10ng/mL

CXC-chemokine receptor 4 (CXCR4), Human, ELISA Kit - CSB-E12825h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

Cytosol aminopeptidase, LAP3, Human, ELISA Kit - E0536h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Leucine aminopeptidase 3 (LAP3), Human, ELISA Kit - E01L0320 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

CXCR4 (Phospho-Ser339) Colorimetric Cell-Based ELISA Kit - CBP1352 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human CXCR4(Chemokine C-X-C-Motif Receptor 4) ELISA Kit - E-EL-H5490 from Elabscience Category ELISA Kit Sensitivity 46.88 pg/mL Range 78.13—5000 pg/mL

chemokine (C-X-C motif) receptor 4, ELISA Kit - MBS701992 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human CXCR4 is typically less than 3.9 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 15.6 pg/ml -1000 pg/ml.

Chemokine C-X-C-Motif Receptor 4, ELISA Kit - MBS749352 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Chemokine C-X-C-Motif Receptor 4, ELISA Kit - MBS753796 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Chemokine C-X-C-Motif Receptor 4, ELISA Kit - MBS754878 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Chemokine C-X-C-Motif Receptor 4, ELISA Kit - MBS747483 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Chemokine C-X-C-Motif Receptor 4, ELISA Kit - MBS748527 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Chemokine C-X-C-Motif Receptor 4, ELISA Kit - MBS749298 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Chemokine C-X-C-Motif Receptor 4, ELISA Kit - MBS744447 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Chemokine C-X-C-Motif Receptor 4 (CXCR4), ELISA Kit - MBS2021892 from MyBioSource Category ELISA Kit Prices $345.00, $515.00, $695.00, $2,840.00, $5,180.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.055ng/mL. Range 0.156-10ng/mL

Chemokine C-X-C-Motif Receptor 4 (CXCR4), ELISA Kit - MBS2022474 from MyBioSource Category ELISA Kit Prices $350.00, $525.00, $715.00, $2,915.00, $5,315.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 27pg/mL. Range 78.13-5000pg/mL

Chemokine C-X-C-Motif Receptor 4 (CXCR4) - MBS9309307 from MyBioSource Category ELISA Kit Prices $435.00, $600.00 Sizes 48 strip wells, 96 strip wells

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