| Gene Symbol |
Qk
|
| Entrez Gene |
19317
|
| Alt Symbol |
1110003F05Rik, 1500005P18, QkI, l(17)-1Wis, l17Wis1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
quaking
|
| Other Description |
QKI-5 protein|lethal, Chr 17, U Wisconsin 1|protein quaking
|
| Swissprots |
Q9QUH4 Q78ZE5 Q9Z246 Q9QYS9 Q8K4X9 Q9R2A8 Q8K4Y0 O88972 Q9CW34 Q61110 Q78ZE4
|
| Accessions |
AAD53329 AAD53330 AAD53331 AAD53332 AAM21005 AAM21006 AAM21007 AAM21008 AAM21009 AAM21010 CAB37614 CAB37615 CAB37616 EDL02087 EDL02088 EDL02089 Q9QYS9 AF090402 AAC99452 AF090403 AAC99453 AF091047 AAC63042 AK003349 AK005169 BAB23859 AK010134 AK020722 AK033279 AK132303 BAE21091 AK142236 BAE24988 AK150706 AK161210 AK163757 AK168411 BB674938 BC053426 AAH53426 BC056346 AAH56346 U44940 AAC52491 U44941 AAC52492 XM_006523300 XP_006523363 XR_385167 XR_385168 XR_385169 XR_385170 NM_001159516 NP_001152988 NM_001159517 NP_001152989 NM_021881 NP_068681
|
| Function |
RNA-binding protein that plays a central role in myelinization. Also required for visceral endoderm function and blood vessel development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation, as well as cellular processes including apoptosis, cell cycle, glial cell fate and development. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Isoform 1 is involved in regulation of mRNA splicing of MAG pre-mRNA by acting as a negative regulator of MAG exon 12 alternative splicing. Isoform 3 can induce apoptosis, while heterodimerization with other isoforms results in nuclear translocation of isoform 3 and suppression of apoptosis. Isoform 4 acts as a translational repressor for GLI1. May also play a role in smooth muscle development. {ECO:0000269|PubMe
|
| Subcellular Location |
Isoform 3: Cytoplasm. Nucleus. Note=Isoform 3 localizes predominantly in the cytoplasm and at much lower levels in nucleus.
|
| Tissue Specificity |
Highly expressed in myelin-forming cells. Expressed in oligodendrocytes and astrocytes in the central nervous system as well as Schwann cells in the peripheral nervous system. Also expressed in the yolk sac endoderm, adjacent to the mesodermal site of developing blood islands, where the differentiation of blood and endothelial cells first occurs (at protein level). Expressed in brain, lung, heart and testis. {ECO:0000269|PubMed:8589716, ECO:0000269|PubMed:8987822, ECO:0000269|PubMed:9778149}.
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