POLH

Gene Symbol POLH
Entrez Gene 5429
Alt Symbol RAD30, RAD30A, XP-V, XPV
Species Human
Gene Type protein-coding
Description polymerase (DNA directed), eta
Other Description DNA polymerase eta|RAD30 homolog A|xeroderma pigmentosum variant type protein
Swissprots Q9Y253 Q9BX13 Q96BC4 Q7L8E3
Accessions AAQ81300 ACQ91143 BAB18601 EAX04209 EAX04210 EAX04211 EAX04212 Q9Y253 AB024313 BAA81666 AF158185 AAD43810 AF241258 AJ420484 AK023893 BAG51237 AK025631 AK122807 BAG53738 AK294430 BAG57675 AK307660 AK316151 BAH14522 BC015742 AAH15742 DC416114 XM_005249186 XP_005249243 XM_011514698 XP_011513000 NM_001291969 NP_001278898 NM_001291970 NP_001278899 NM_006502 NP_006493
Function DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci. {ECO:0000269|PubMed:10385124, ECO:0000269|PubMed:11376341, ECO:0000269|PubMed:11743006, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:14734526}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12606586}. Note=Accumulates at replication forks after DNA damage.
Top Pathways Fanconi anemia pathway

POL H CRISPR/Cas9 KO Plasmid (h) - sc-401794 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

POL H HDR Plasmid (h) - sc-401794-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POL H Double Nickase Plasmid (h) - sc-401794-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POL H Double Nickase Plasmid (h2) - sc-401794-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POL H CRISPR Activation Plasmid (h) - sc-401794-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

POL H CRISPR Activation Plasmid (h2) - sc-401794-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

POL H Lentiviral Activation Particles (h) - sc-401794-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POL H Lentiviral Activation Particles (h2) - sc-401794-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POL H siRNA (h) - sc-36289 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

POL H shRNA Plasmid (h) - sc-36289-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

POL H shRNA (h) Lentiviral Particles - sc-36289-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU004141 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17099 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17099 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08195 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08195

POLH siRNA (Human) - CRH3632 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human POLH (NM_006502.2) - SHH379236 from Creative biogene

Category siRNA
Species Reactivities Human

Human DNA Polymerase theta siRNA - orb264134 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

POLH shRNA Plasmid (Human) - CHH3632 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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