| Gene Symbol |
TTLL3
|
| Entrez Gene |
26140
|
| Alt Symbol |
HOTTL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tubulin tyrosine ligase-like family member 3
|
| Other Description |
tubulin monoglycylase TTLL3|tubulin tyrosine ligase-like family, member 3|tubulin--tyrosine ligase-like protein 3
|
| Swissprots |
Q9UI99 Q96GG8 Q6ZU95 Q8NDN8 Q6AWA3 Q9Y4R7 Q9H876 Q4KMS8
|
| Accessions |
Q9Y4R7 AA742169 AF078842 AAF23353 AK023960 BAB14741 AK097236 AK125875 AK297289 BAG59759 AK315140 BAG37589 AL096725 CAB46375 AL833939 CAD38794 BC009479 BC028169 BC098298 AAH98298 BC098361 AAH98361 BC099735 AAH99735 BC105638 AAI05639 BM674442 BM717061 BP357921 BX440835 CB854808 DA267460 NM_015644 NM_001025930 NP_001021100 NR_037162
|
| Function |
Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction. {ECO:0000269|PubMed:19524510}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}.
|