SLIT2

Gene Symbol	SLIT2
Entrez Gene	9353
Alt Symbol	SLIL3, Slit-2
Species	Human
Gene Type	protein-coding
Description	slit homolog 2 (Drosophila)
Other Description	slit homolog 2 protein
Swissprots	B7ZLR5 O95710 O94813 Q17RU3 Q9Y5Q7
Accessions	AAY41008 AAY41010 EAW92792 EAW92793 O94813 AA489463 AB017168 BAA35185 AF055585 AAD04309 AF133270 AAD25539 AK027326 BAG51304 AK126459 AK308444 BC117190 AAI17191 BC143978 AAI43979 BF112143 BI494498 BM474839 CV370469 DB207352 XM_005248211 XP_005248268 XM_006713986 XP_006714049 XM_011513909 XP_011512211 XM_011513910 XP_011512212 NM_001289135 NP_001276064 NM_001289136 NP_001276065 NM_004787 NP_004778
Function	Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth- stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post- crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for
Subcellular Location	Secreted {ECO:0000269|PubMed:10102268}. Note=The C-terminal cleavage protein is more diffusible than the larger N-terminal protein that is more tightly cell associated.
Tissue Specificity	Fetal lung and kidney, and adult spinal cord. Weak expression in adult adrenal gland, thyroid, trachea and other tissues examined. {ECO:0000269|PubMed:10349621, ECO:0000269|PubMed:9813312}.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rat SLIT2 ELISA Kit (Sandwich ELISA) - LS-F6346 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 30 pg/ml Range 1.56-100 ng/ml

Human SLIT2 ELISA Kit (Sandwich ELISA) - LS-F4840 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 1.56 ng/ml Range 1.56-100 ng/ml

Mouse SLIT2 ELISA Kit (Sandwich ELISA) - LS-F4841 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 78 pg/ml Range 1.56-100 ng/ml

Human SLIT2 ELISA Kit (Sandwich ELISA) - LS-F12612 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 1.56-100 ng/ml

Slit Homolog 2 (Slit2), Human, ELISA Kit - SEA672Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 24pg/mL Range 78-5,000pg/mL

Slit2, Human, ELISA Kit - CSB-E11038h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.195 ng/ml Range 0.78 ng/ml-50 ng/ml

Slit Homolog 2, ELISA Kit - MBS030214 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Slit Homolog 2, ELISA Kit - MBS108294 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Slit Homolog 2, ELISA Kit - MBS725512 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Slit Homolog 2, ELISA Kit - MBS734475 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Slit Homolog 2, ELISA Kit - MBS016413 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Slit Homolog 2, ELISA Kit - MBS089132 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Slit Homolog 2, ELISA Kit - MBS024108 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Slit Homolog 2, ELISA Kit - MBS038201 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Slit Homolog 2, ELISA Kit - MBS025658 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Slit Homolog 2, ELISA Kit - MBS734019 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Slit Homolog 2, ELISA Kit - MBS008778 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Slit Homolog 2, ELISA Kit - MBS083294 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Slit Homolog 2, ELISA Kit - MBS737662 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Slit Homolog 2, ELISA Kit - MBS741517 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Slit Homolog 2, ELISA Kit - MBS045973 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Slit Homolog 2, ELISA Kit - MBS739480 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Slit Homolog 2, ELISA Kit - MBS073116 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Slit Homolog 2, ELISA Kit - MBS008863 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Slit Homolog 2, ELISA Kit - MBS018338 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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