Gene Symbol | PPT1 |
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Entrez Gene | 5538 |
Alt Symbol | CLN1, INCL, PPT |
Species | Human |
Gene Type | protein-coding |
Description | palmitoyl-protein thioesterase 1 |
Other Description | ceroid-palmitoyl-palmitoyl-protein thioesterase 1|palmitoyl-protein hydrolase 1 |
Swissprots | Q6FGQ4 B4DY24 P50897 |
Accessions | AAA85337 AAB72224 CBX51404 EAX07237 EAX07238 P50897 AK075496 AK301682 BAG63155 AK302232 BAG63586 AK310799 AK312287 BAG35214 BC008426 AAH08426 BX441569 CR542053 CAG46850 DA504318 HQ447414 ADQ31900 U44772 AAB06236 XM_005271008 XP_005271065 NM_000310 NP_000301 NM_001142604 NP_001136076 |
Function | Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons. |
Subcellular Location | Lysosome. |
Top Pathways | Lysosome, Fatty acid elongation, Fatty acid metabolism |
CLN1 CRISPR/Cas9 KO Plasmid (h) - sc-404018 from Santa Cruz Biotechnology
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CLN1 HDR Plasmid (h) - sc-404018-HDR from Santa Cruz Biotechnology
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CLN1 Double Nickase Plasmid (h) - sc-404018-NIC from Santa Cruz Biotechnology
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CLN1 Double Nickase Plasmid (h2) - sc-404018-NIC-2 from Santa Cruz Biotechnology
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CLN1 CRISPR Activation Plasmid (h) - sc-404018-ACT from Santa Cruz Biotechnology
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CLN1 CRISPR Activation Plasmid (h2) - sc-404018-ACT-2 from Santa Cruz Biotechnology
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CLN1 Lentiviral Activation Particles (h) - sc-404018-LAC from Santa Cruz Biotechnology
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CLN1 Lentiviral Activation Particles (h2) - sc-404018-LAC-2 from Santa Cruz Biotechnology
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CLN1 siRNA (h) - sc-105216 from Santa Cruz Biotechnology
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CLN1 shRNA Plasmid (h) - sc-105216-SH from Santa Cruz Biotechnology
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CLN1 shRNA (h) Lentiviral Particles - sc-105216-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU016501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17322 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17322 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09153 from Sigma-Aldrich
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PPT1 siRNA (Human) - CRH3717 from Cohesion Biosciences
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CLN1 CRISPR/Cas9 KO Plasmid (h2) - sc-404018-KO-2 from Santa Cruz Biotechnology
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CLN1 HDR Plasmid (h2) - sc-404018-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human PPT1 (NM_000310.3) - SHH381724 from Creative biogene
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Human PPT1 siRNA - orb264219 from Biorbyt
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PPT1 shRNA Plasmid (Human) - CHH3717 from Cohesion Biosciences
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PPT1 miRNA 3'UTR clone - MiUTR3H-03590 from Creative biogene
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PPT1 miRNA 3'UTR clone - MiUTR3H-03591 from Creative biogene
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