| Gene Symbol |
VPS51
|
| Entrez Gene |
738
|
| Alt Symbol |
ANG2, ANG3, C11orf2, C11orf3, FFR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
vacuolar protein sorting 51 homolog (S. cerevisiae)
|
| Other Description |
another new gene 2 protein|protein fat-free homolog|vacuolar protein sorting-associated protein 51 homolog
|
| Swissprots |
Q9UID3 Q6PJV5 Q8WZ35 Q96GR3 Q7L8A6 Q96DF4
|
| Accessions |
EAW74347 Q9UID3 AF024631 AAF21627 AK023941 AK093791 AL833818 CAD38681 AW007399 BC006555 AAH06555 BC007198 AAH07198 BC009285 AAH09285 BC010540 AAH10540 BC010872 BC017438 AAH17438 BG391473 BI752026 BI823833 BI828867 BX401315 CD388131 HY270070 NM_013265 NP_037397 NR_073519
|
| Function |
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi networkl (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. {ECO:0000269|PubMed:20685960}.
|
| Subcellular Location |
Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:20685960}.
|