CACNA1B

Gene Symbol CACNA1B
Entrez Gene 774
Alt Symbol BIII, CACNL1A5, CACNN, Cav2.2, DYT23
Species Human
Gene Type protein-coding
Description calcium channel, voltage-dependent, N type, alpha 1B subunit
Other Description Cav2.2 voltage-gated Ca2+ channel|brain calcium channel III|calcium channel alpha12.2 subunit|calcium channel, L type, alpha-1 polypeptide|calcium channel, N type|calcium channel, voltage-dependent, L type, alpha 1B subunit|calcium channel, voltage-dependent, alpha 1B subunit, N type|voltage-dependent N-type calcium channel subunit alpha-1B|voltage-gated calcium channel alpha subunit Cav2.2|voltage-gated calcium channel subunit alpha Cav2.2
Swissprots B1AQK5 Q00975
Accessions AAC51138 AAG13642 AAG13643 AAG13644 AAG13645 AAG13646 AAG13647 AAG13648 AAG13650 AAG14396 AAG14397 AAG14398 CAJ41866 EAW88415 EAW88416 EAW88417 EAW88418 Q00975 AB209467 BAD92704 AY429522 AY429523 BC033060 M94172 AAA51897 M94173 AAA51898 XM_011518990 XP_011517292 XM_011518991 XP_011517293 XM_011518992 XP_011517294 XM_011518993 XP_011517295 XM_011518994 XP_011517296 XM_011518995 XP_011517297 XM_011518996 XP_011517298 XM_011518997 XP_011517299 NM_000718 NP_000709 NM_001243812 NP_001230741
Function Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta.
Top Pathways GABAergic synapse, Retrograde endocannabinoid signaling, Nicotine addiction, Morphine addiction, Dopaminergic synapse

N-type Ca ++ CP α1B (A-11) - sc-271010 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
N-type C<sup>++</sup> CP α1B (A-11): sc-271010. Western blot analysis of N-type Ca<sup>++</sup> CP α1B expression in IMR-32 whole cell lysate.

N-type Ca ++ CP α1B (W-15) - sc-32085 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
N-type Ca<sup>++</sup> CP α1B (W-15): sc-32085. Western blot analysis of N-type Ca<sup>++</sup> CP α1B expression in IMR-32 whole cell lysate.

N-type Ca ++ CP α1B (A-2) - sc-377489 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
N-type Ca<sup>++</sup> CP α1B (A-2): sc-377489. Western blot analysis of N-type Ca<sup>++</sup> CP α1B expression in U-87 MG whole cell lysate.

N-type Ca ++ CP α1B (C-19) - sc-32087 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
N-type Ca<sup>++</sup> CP α1B (C-19): sc-32087. Western blot analysis of N-type Ca<sup>++</sup> CP α1B expression in U-87 MG (A), PC-12 (B) and SK-N-SH (C) whole cell lysates.

N-type Ca ++ CP α1B (P-15) - sc-15955 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
N-type Ca<sup>++</sup> CP α1B (P-15): sc-15955. Western blot analysis of N-type Ca<sup>++</sup> CP α1B expression in mouse brain (A) and rat brain (B) tissue extracts.

N-type Ca ++ CP α1B (H-155) - sc-20129 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
N-type Ca<sup>++</sup> CP α1B (H-155): sc-20129. Western blot analysis of N-type Ca<sup>++</sup> CP α1B expression in SH-SY5Y whole cell lysate.

N-type Ca ++ CP α1B (L-17) - sc-32083 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

N-type Ca ++ CP α1B (S-18) - sc-32084 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
N-type Ca<sup>++</sup> CP α1B (S-18): sc-32084. Western blot analysis of N-type Ca<sup>++</sup> CP α1B expression in SH-SY5Y (A) and IMR-32 (B) whole cell lysates and mouse brain (C) and rat brain (D) tissue extracts.

N-type Ca ++ CP α1B (N-14) - sc-15954 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CACNA1B (N type) antibody - ab97284 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
IHC image of CACNA1B (N type) staining in human cerebral cortex formalin fixed paraffin embedded tissue section, performed on a Leica Bond system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab97284, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-CACNA1B (N type) antibody - ab81012 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-CACNA1B (N type) antibody - ab66426 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA1B (N type) antibody - ab55949 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CACNA1B (N type) antibody - ab93891 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-CACNA1B / Cav2.2 Antibody (aa2013-2209) - LS-C185486 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence of methanol-fixed A549 using CACNA1B antibody at 1:500 dilution.

Anti-CACNA1B / Cav2.2 Antibody - LS-C26746 from LifeSpan Bioscience

Prices $330.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CACNA1B / Cav2.2 Antibody (C-Terminus) - LS-C47021 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CACNA1B / Cav2.2 Antibody (N-Terminus) - LS-C144758 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA1B / Cav2.2 Antibody - LS-C140726 from LifeSpan Bioscience

Prices $460.00
Sizes 10 blot
Host Rabbit
Clonality Polyclonal

Anti-CACNA1B / Cav2.2 Antibody (N-Terminus) - LS-C153506 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Cav2.2 Antibody - NBP1-20103 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Cav2.2 Antibody - NBP1-91744 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Cav2.2 Antibody [NBP1-91744] - Staining of human cerebral cortex shows moderate cytoplasmic positivity in glial cells.

CACNA1B (N type) Polyclonal Antibody - bs-10490R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CACNA1B (N type) Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-10490R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CACNA1B (N type) Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-10490R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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