Gene Symbol | ACADVL |
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Entrez Gene | 37 |
Alt Symbol | ACAD6, LCACD, VLCAD |
Species | Human |
Gene Type | protein-coding |
Description | acyl-CoA dehydrogenase, very long chain |
Other Description | acyl-Coenzyme A dehydrogenase, very long chain|very long-chain specific acyl-CoA dehydrogenase, mitochondrial |
Swissprots | O76056 F5H2A9 B4DEB6 P49748 Q8WUL0 |
Accessions | AAA79002 AIL83881 BAA29057 EAW90246 EAW90247 EAW90248 EAW90249 EAW90250 P49748 AA643658 AK056083 BAG51618 AK056956 BAG51833 AK058109 AK097243 AK222518 BAD96238 AK293549 BAG57027 AK302653 BAG63892 AL536186 BC000399 AAH00399 BC012912 AAH12912 BC020218 AAH20218 BI822737 BP387474 D43682 BAA07781 DA945553 X86556 CAA60253 XM_006721516 XP_006721579 XM_011523829 XP_011522131 XM_011523830 XP_011522132 XR_934021 XR_934022 XR_934023 NM_000018 NP_000009 NM_001033859 NP_001029031 NM_001270447 NP_001257376 NM_001270448 NP_001257377 |
Function | Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons. {ECO:0000269|PubMed:18227065}. |
Subcellular Location | Mitochondrion inner membrane. |
Top Pathways | Fatty acid degradation, Fatty acid metabolism |
ACADVL (VLCAD) CRISPR/Cas9 KO Plasmid (h) - sc-403111 from Santa Cruz Biotechnology
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ACADVL (VLCAD) HDR Plasmid (h) - sc-403111-HDR from Santa Cruz Biotechnology
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ACADVL (VLCAD) Double Nickase Plasmid (h) - sc-403111-NIC from Santa Cruz Biotechnology
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ACADVL (VLCAD) Double Nickase Plasmid (h2) - sc-403111-NIC-2 from Santa Cruz Biotechnology
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ACADVL (VLCAD) CRISPR Activation Plasmid (h) - sc-403111-ACT from Santa Cruz Biotechnology
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ACADVL (VLCAD) CRISPR Activation Plasmid (h2) - sc-403111-ACT-2 from Santa Cruz Biotechnology
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ACADVL (VLCAD) Lentiviral Activation Particles (h) - sc-403111-LAC from Santa Cruz Biotechnology
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ACADVL (VLCAD) Lentiviral Activation Particles (h2) - sc-403111-LAC-2 from Santa Cruz Biotechnology
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ACADVL siRNA (h) - sc-72427 from Santa Cruz Biotechnology
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ACADVL shRNA Plasmid shRNA Plasmid (h) - sc-72427-SH from Santa Cruz Biotechnology
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ACADVL shRNA (h) Lentiviral Particles - sc-72427-V from Santa Cruz Biotechnology
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ACADVL RNAi - H00000037-R01 from Novus Biologicals
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ACADVL RNAi - H00000037-R02 from Novus Biologicals
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MISSION® esiRNA - EHU068431 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2695 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2695 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00615 from Sigma-Aldrich
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ACADVL siRNA (Human) - CRH0029 from Cohesion Biosciences
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ACADVL - MBS8214824 from MyBioSource
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ACADVL (VLCAD) CRISPR/Cas9 KO Plasmid (h2) - sc-403111-KO-2 from Santa Cruz Biotechnology
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ACADVL (VLCAD) HDR Plasmid (h2) - sc-403111-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human ACADVL (NM_000018.3) - SHH229962 from Creative biogene
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Human ACADVL siRNA - orb260531 from Biorbyt
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ACADVL shRNA Plasmid (Human) - CHH0029 from Cohesion Biosciences
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ACADVL miRNA 3'UTR clone - MiUTR3H-10691 from Creative biogene
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