| Gene Symbol | CHST11 |
|---|---|
| Entrez Gene | 50515 |
| Alt Symbol | C4ST, C4ST-1, C4ST1, HSA269537 |
| Species | Human |
| Gene Type | protein-coding |
| Description | carbohydrate (chondroitin 4) sulfotransferase 11 |
| Other Description | C4S-1|IgH/CHST11 fusion|carbohydrate sulfotransferase 11|chondroitin 4-O-sulfotransferase 1 |
| Swissprots | Q9NY36 A8K4F8 Q9NXY6 Q9NPF2 |
| Accessions | EAW97748 EAW97749 EAW97750 Q9NPF2 AB042326 BAA95485 AF131762 AF239820 AAF81691 AJ269537 CAB87380 AJ289134 CAB92134 AK123676 AK290923 BAF83612 AK313217 AL833176 AY533204 AAU87522 AY533205 AAU87523 BC013315 AAH13315 BC030271 BC061524 DA853534 HQ447191 ADQ31678 NM_001173982 NP_001167453 NM_018413 NP_060883 |
| Function | Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6- di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Widely expressed. Highly expressed in spleen, thymus, bone marrow, peripheral blood leukocytes, lymph node, heart, brain, lung and placenta. {ECO:0000269|PubMed:10781601, ECO:0000269|PubMed:11056388}. |
| Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |