| Gene Symbol |
RAB7A
|
| Entrez Gene |
100008682
|
| Alt Symbol |
RAB7
|
| Species |
Rabbit
|
| Gene Type |
protein-coding
|
| Description |
RAB7A, member RAS oncogene family
|
| Other Description |
ras-related protein Rab-7a
|
| Swissprots |
O97572
|
| Accessions |
O97572 AF050174 AAD02564 XM_008260198 XP_008258420 NM_001082034 NP_001075503
|
| Function |
Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacteria. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the li
|
| Subcellular Location |
Late endosome. Lysosome {ECO:0000250}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Melanosome {ECO:0000250}. Note=Colocalizes with OSBPL1A at the late endosome. Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Recruited to phagosomes containing S.aureus or Mycobacterium (By similarity). {ECO:0000250}.
|
| Top Pathways |
Endocytosis, Phagosome, Amoebiasis, Salmonella infection, Tuberculosis
|