NR5A2

Gene Symbol NR5A2
Entrez Gene 2494
Alt Symbol B1F, B1F2, CPF, FTF, FTZ-F1, FTZ-F1beta, LRH-1, LRH1, hB1F-2
Species Human
Gene Type protein-coding
Description nuclear receptor subfamily 5, group A, member 2
Other Description CYP7A promoter-binding factor|alpha-1-fetoprotein transcription factor|b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus|fetoprotein-alpha 1 (AFP) transcription factor|hepatocytic transcription factor hB1F-3|liver nuclear receptor homolog-1 variant 2|liver receptor homolog 1|liver receptor homolog-1|nuclear receptor NR5A2|nuclear receptor subfamily 5 group A member 2
Swissprots Q147U3 O95642 B4E2P3 O00482
Accessions AAG17124 AAG17125 AAL37171 ACD87739 EAW91305 EAW91306 EAW91307 EAW91308 O00482 AB019246 BAA34092 AB307719 BAH02310 AF049102 AAD03248 AF112344 AF124247 AAD26565 AF124248 AAD26566 AF146343 AAD37378 AF228413 AK304344 BAG65188 AK304365 BAG65205 AK308446 AK316513 BAH14884 BC027893 BC118571 AAI18572 BC118652 AAI18653 CA776772 CB162803 HQ692857 ADZ17368 U80251 AAC78727 U93553 AAD03155 XM_005245062 XP_005245119 XM_011509380 XP_011507682 XM_011509381 XP_011507683 XM_011509382 XP_011507684 XM_011509383 XP_011507685 XM_011509384 XP_011507686 NM_001276464 NP_001263393 NM_003822 NP_003813 NM_205860 NP_995582
Function Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
Subcellular Location Nucleus {ECO:0000305}.
Tissue Specificity Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in the Hep-G2 cell line. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and Hep-G2 cells.
Top Pathways Maturity onset diabetes of the young

NR5A2 (E-9) - sc-398349 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NR5A2 (E-9): sc-398349. Western blot analysis of NR5A2 expression in mouse pancreas tissue extract.

NR5A2 (H-75) - sc-25389 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NR5A2 (H-75): sc-25389. Immunofluorescence staining of normal mouse intestine frozen section showing nuclear staining.

NR5A2 (C-17) - sc-21132 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NR5A2 (B-8) - sc-393369 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NR5A2 (B-8): sc-393369. Western blot analysis of NR5A2 expression in mouse pancreas tissue extract.

NR5A2 (L-15) - sc-5995 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NR5A2 (N-15) - sc-5997 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NR5A2 (N-15): sc-5997. Western blot analysis of human recombinant NR5A2 fusion protein.

NR5A2 (M-14) - sc-21133 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NR5A2 (M-14): sc-21133. Western blot analysis of NR5A2 expression in mouse pancreas tissue extract.

NR5A2 (N-16) - sc-5993 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NR5A2 (N-16): sc-5993. Western blot analysis of human recombinant NR5A2 fusion protein.

NR5A2 (V-14) - sc-5998 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NR5A2 (V-14): sc-5998. Western blot analysis of human recombinant NR5A2 fusion protein.

NR5A2 (S-24) - sc-133844 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
NR5A2 (S-24): sc-133844. Western blot analysis of NR5A2 expression in Hep G2 whole cell lysate.

Anti-NR5A2 / LRH1 antibody - ab130695 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-NR5A2 / LRH1 antibody (ab130695) at 1/100 dilution + 293 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-NR5A2 / LRH1 antibody [EPR7000] - ab125034 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7000
All lanes : Anti-NR5A2 / LRH1 antibody [EPR7000] (ab125034) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : BxPC3 cell lysateLane 3 : HepG2 cell lysateLane 4 : MCF7 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti rabbit at 1/2000 dilution

Anti-NR5A2 / LRH1 antibody [H2325] - ab41901 from Abcam

Prices $379.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone H2325
All lanes : Anti-NR5A2 / LRH1 antibody [H2325] (ab41901) at 1/1000 dilutionLane 1 : COS-1 cells transfected with NR5A2Lane 2 : COS-1 cells transfected with NR5A2Lane 3 : COS-1 cells transfected with NR5A2Lane 4 : COS-1 cells transfected with NR5A2Lane 5 : COS-1 cells transfected with NR5A2Lane 6 : COS-1 cells transfected with NR5A2Lane 7 : COS-1 cells transfected with NR5A2Lane 8 : COS-1 cells transfected with NR5A2Lysates/proteins at 15 µg per lane.SecondaryHRP-conjugated Goat anti-Mouse IgG polyclonal at 1/2500 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-NR5A2 / LRH1 antibody [K8801] - ab41900 from Abcam

Prices $373.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone K8801

Anti-NR5A2 / LRH1 antibody - C-terminal - ab189876 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of A549 cells using ab189876. Blue DAPI for nuclear staining.

Anti-NR5A2 / LRH-1 Antibody (Ligand-binding Domain) IHC-plus™ - LS-A2566 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NR5A2 antibody LS-A2566 IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-NR5A2 / LRH-1 Antibody (Internal, clone EPR7000) - LS-C139026 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7000
Western blot analysis on (A) HeLa, (B) BxPC-3, (C) HepG2, and (D) MCF-7 cell lysates using anti-NR5A2 antibody.

Anti-NR5A2 / LRH-1 Antibody (aa313-342, AP) - LS-C264749 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR5A2 / LRH-1 Antibody (N-Terminus) - LS-C40309 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
NR5A2 antibody LS-C40309 Western blot of HepG2 cell lysate.

Anti-NR5A2 / LRH-1 Antibody (aa313-342, APC) - LS-C264750 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR5A2 / LRH-1 Antibody (aa313-342, Biotin) - LS-C264751 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR5A2 / LRH-1 Antibody (aa313-342, FITC) - LS-C264752 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR5A2 / LRH-1 Antibody (Internal) IHC-plus™ - LS-A2453 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-NR5A2 / LRH-1 Antibody (aa233-246) - LS-C205043 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
NR5A2 antibody (1 ug/ml) staining of HepG2 nuclear lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-NR5A2 / LRH-1 Antibody (aa313-342, Azide-free, HRP) - LS-C264753 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Search more