CFTR

Gene Symbol CFTR
Entrez Gene 1080
Alt Symbol ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1
Species Human
Gene Type protein-coding
Description cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Other Description cAMP-dependent chloride channel|channel conductance-controlling ATPase|cystic fibrosis transmembrane conductance regulator
Swissprots Q20BG8 Q2I102 Q2I0A1 Q20BH2 P13569
Accessions AAA51979 AAA51980 AAA51982 AAB46340 AAB46352 AAB59382 AAC13657 AAC41927 AAC41928 AAW33655 AAW33656 AAW33657 AAW33658 AAW33659 AAW33782 ABC79050 ABC79052 ABC79054 ABC79056 ABC87053 ABC87055 ABC87057 ABC87059 ABC87061 ABC87063 ABC87065 ABC87067 ABD72183 ABD72185 ABD72187 ABD72189 ABD72191 ABD72193 ABD72195 ABD72197 ABD72199 ABD72201 ABD72203 ABD72205 ABD72207 ABD72209 ABD72211 ABD72213 ABD72215 ABD72217 ABF72845 ABO61515 AFP72354 AFP72355 AIC64237 AIO11142 AIO11143 AIQ84249 AIQ84250 AIS25620 AIS25621 AIS25622 AIS25623 AIS25624 AIS25625 AIS25626 AIS25627 AIS25628 AIZ78009 CAE00653 CAE00654 CAE00655 CAE00656 CAE00657 CAE00658 CAE00659 CAE00660 CAE00661 CAE00662 CAE00663 CAE00664 CAE00665 CAE00666 CAE00667 CAE00668 CAE00669 CAE00670 CAE00671 CAE00672 CAE00673 CAE00674 CAE00675 CAE00676 CAE00677 CAE00678 CAE00679 CAE00680 CAE00681 CAE00682 CAE00683 CAE00684 CAE00685 CAE00686 CAE00687 CAE00688 CAE00689 CAE00690 CAE00691 CAE00692 CAE00693 CAE00694 CAE00695 CAE00696 CAE00697 CAE00698 CAE00699 CAE00700 CAE00701 CAE00702 CAE00703 CAE00704 CAE00705 CAE00706 CAE00707 CAE00708 CAE00709 CAE00710 CAE00711 CAE00712 CAE00713 CAE00714 CAE00715 CAE00716 CAE00717 CAE00718 CAE00719 CAE00720 CAE00721 CAE00722 CAE00723 CAE00724 CAE00725 CAE00726 CAE00727 CAE00728 CAE00729 CAE00730 CAE00731 CAE00732 CAE00733 CAE00734 CAE00735 CAE00736 CAE00737 CAE00738 CAE00739 CAE00740 CAE00741 CAE00742 CAE00743 CAE00744 CAE00745 CAE00746 CAE00747 CAE00748 CAE00749 CAE00750 CAE00751 CAE00752 CAE00753 CAE00754 CAE00755 CAE00756 CAE00757 CAE00758 CAE00759 CAE00760 CAE00761 CAE00762 CAE00763 CAE00764 CAE00765 CAE00766 CAE00767 CAE00768 CAE00769 EAL24353 EAW83529 EAW83530 EAW83531 P13569 BC143713 BC156254 AAI56255 M28668 AAA35680 S64699 AAB27879 S82430 AAD14390 X73053 XM_011515751 XP_011514053 XM_011515752 XP_011514054 XM_011515753 XP_011514055 XM_011515754 XP_011514056 NM_000492 NP_000483
Function Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation. {ECO:0000269|PubMed:22178883}.
Subcellular Location Early endosome membrane; Multi-pass membrane protein. Cell membrane. Note=In the oviduct and bronchus, detected on the apical side of epithelial cells, but not associated with cilia. {ECO:0000269|PubMed:22207244}.
Tissue Specificity Expressed in the respiratory airway, including bronchial epithelium, and in the female reproductive tract, including oviduct (at protein level). {ECO:0000269|PubMed:22207244}.
Top Pathways ABC transporters, Vibrio cholerae infection, Gastric acid secretion, Pancreatic secretion, Bile secretion

CFTR Antibody - 2269 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of human airway epithelial cells, Calu-3 (expressing endogenous CFTR) and CFBE41o- (stably expressing WT-CFTR or deltaF508-CFTR), using CFTR Antibody. Kindly provided by Dr. Agnes Swiatecka-Urban and Dr. Bruce A. Stanton, Department of Physiology, Dartmouth Medical School, Hanover, NH.

CFTR (A-3) - sc-376683 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CFTR (A-3): sc-376683. Western blot analysis of CFTR expression in AMJ2-C8 whole cell lysate.

CFTR (C-19) - sc-8910 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CFTR (C-19): sc-8910. Western blot analysis of CFTR expression in CFTR-transfected BHK cells.

CFTR (H-182) - sc-10747 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CFTR (H-182): sc-10747. Western blot analysis of CFTR expression in MH-S (A) and AMJ2-C8 (B) whole cell lysates.

CFTR (GA1) - sc-20074 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CFTR (GA1): sc-20074. Western blot analysis of CFTR expression in CFTR-transfected BHK cells.

CFTR (N-20) - sc-8909 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CFTR (N-20): sc-8909. Western blot analysis of CFTR expression in rat lung tissue extract.

CFTR (M3A7) - sc-58615 from Santa Cruz Biotechnology

Prices $279.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal

Anti-CFTR antibody - ab181782 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CFTR antibody (ab181782) at 1/500 dilutionLane 1 : BHK cellsLane 2 : BHK cells transfected with CFTR-3HA tagLane 3 : Immunprecipitated wt CFTR from BHK cells

Anti-CFTR antibody - ab59394 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using ab59394 at a 1/50 dilution. Left image: un-treated. Right image: treated with peptide.

Anti-CFTR antibody [M3A7] - ab4067 from Abcam

Host Mouse
Clonality Monoclonal
Clone M3A7
ab4067 staining human tonsil by IHC-P.

Anti-CFTR antibody - C-terminal - ab191579 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CFTR antibody - C-terminal (ab191579) at 1 µg/ml + Human small intestine tissue lysate at 15 µg

Anti-CFTR antibody - Carboxyterminal end - ab56058 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CFTR Antibody (aa103-117) - LS-C14756 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CFTR Antibody (aa103-117) - LS-C14758 from LifeSpan Bioscience

Prices $560.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-CFTR Antibody (aa25-36) - LS-C22596 from LifeSpan Bioscience

Prices $560.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-CFTR Antibody (aa1365-1395) - LS-C22597 from LifeSpan Bioscience

Prices $620.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-CFTR Antibody (N-Terminus) - LS-C36072 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CFTR Antibody (C-Terminus) - LS-C46927 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CFTR Antibody - LS-C86981 from LifeSpan Bioscience

Prices $800.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CFTR Antibody (clone L12B4, Azide-free) - LS-C87634 from LifeSpan Bioscience

Prices $695.00, $1,085.00
Sizes 100 ml, 200 ml
Host Mouse
Clonality Monoclonal
Clone L12B4

Anti-CFTR Antibody (clone M3A7, Azide-free) - LS-C87636 from LifeSpan Bioscience

Prices $715.00, $1,085.00
Sizes 100 µl, 200 µl
Host Mouse
Clonality Monoclonal
Clone M3A7

Anti-CFTR Antibody (clone M3A7) - LS-C87635 from LifeSpan Bioscience

Prices $295.00, $620.00, $1,015.00
Sizes 100 µl, 500 µl, 1 ml
Host Mouse
Clonality Monoclonal
Clone M3A7
Formalin-fixed, paraffin-embedded human pancreas stained with peroxidase-conjugate and AEC chromogen. Note membrane staining of epithelial cells in the intercalated ducts.

Anti-CFTR Antibody (C-Terminus) - LS-C145001 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CFTR Antibody (aa25-36) - LS-C152933 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CFTR Antibody (C-Terminus) - LS-C153425 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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