| Gene Symbol |
Hook2
|
| Entrez Gene |
170833
|
| Alt Symbol |
A630054I03Rik
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
hook homolog 2 (Drosophila)
|
| Other Description |
mHK2|protein Hook homolog 2
|
| Swissprots |
Q8R347 Q66JV2 Q8VCN4 Q99LU2 Q7TMK6 Q8BY47
|
| Accessions |
EDL10980 EDL10981 EDL10982 Q7TMK6 AK030599 AK042048 BAC31143 AK136069 BAE22805 AK145768 BAE26639 AK161612 AK166954 BAE39137 AK169073 BAE40859 AK191641 AV374161 BC002226 AAH02226 BC019486 AAH19486 BC026609 AAH26609 BC029967 BC049908 BC055881 AAH55881 BC080744 AAH80744 CJ084759 XM_006530736 XP_006530799 XM_006530737 XP_006530800 XM_006530738 XP_006530801 XM_006530739 XP_006530802 XM_006530740 XP_006530803 XM_006530741 XP_006530804 XM_006530742 XP_006530805 XM_006530743 XP_006530806 XM_011248323 XP_011246625 XR_387734 XR_387735 XR_387736 XR_878781 NM_001167991 NP_001161463 NM_133255 NP_573518
|
| Function |
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17140400}. Cytoplasm {ECO:0000269|PubMed:17140400}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17140400}. Note=Localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi complex, multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found in close association with microtubules (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in brain, cerebellum, kidney, liver and heart, with highest levels in heart and kidney (at protein level). {ECO:0000269|PubMed:17140400}.
|