RAD51D

Gene Symbol	RAD51D
Entrez Gene	5892
Alt Symbol	BROVCA4, R51H3, RAD51L3, TRAD
Species	Human
Gene Type	protein-coding
Description	RAD51 paralog D
Other Description	DNA repair protein RAD51 homolog 4|RAD51 homolog D|RAD51-like protein 3|recombination repair protein
Swissprots	O75196 E1P637 O75847 O76073 Q9UFU5 O60355 O94908 O43537 O75771 B4DJU7 O75848 O76085
Accessions	AAT38112 EAW80181 EAW80184 EAW80190 EAW80196 O75771 AB013341 BAA25914 AB016223 BAA31747 AB016224 BAA31748 AB016225 BAA31749 AB018360 BAA33779 AB018361 BAA33780 AB018362 BAA33781 AB018363 BAA33782 AB020412 BAA34690 AF034956 AAC39719 AK296241 BAG58959 AK301249 BAG62816 AK302450 BAG63746 AL117459 CAB55937 BC002723 AAH02723 BC014422 AAH14422 BI916871 BX647297 DQ892318 ABM83244 DQ895520 ABM86446 Y15572 CAA75681 NM_001142571 NP_001136043 NM_002878 NP_002869 NM_133629 NP_598332 NR_037711 NR_037712 NM_133627 NM_133628 NM_133630
Function	Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single- stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single- stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM. {ECO:0000269|PubMed:10871607, ECO:0000269|PubMed:11751635, ECO:0000269|PubMed:11834724, ECO:0000269|PubMed:11842113, ECO:0000269|PubMed:12975363, ECO:0000269|PubMed:151094
Subcellular Location	Nucleus {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, telomere.
Tissue Specificity	Expressed in colon, prostate, spleen, testis, ovary, thymus and small intestine. Weakly expressed in leukocytes.
Top Pathways	Homologous recombination

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rad51D (5A8/4) - sc-53431 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Rad51D (5B3/6) - sc-53432 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Rad51D (C-1) - sc-398819 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Rad51D (C-16) - sc-33090 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Rad51D (H-96) - sc-366363 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Rad51D (S-15) - sc-33089 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Rad51D antibody - ab168463 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-Rad51D antibody - ab74036 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Rad51D antibody - ab117942 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Rad51D antibody [EPR16205] - ab202063 from Abcam Prices $99.00, $347.00 Sizes 10 µl, 100 µl Host Rabbit Clonality Monoclonal Clone EPR16205

Anti-Rad51D antibody [Rad51D 5A8/4] - ab11051 from Abcam Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone Rad51D 5A8/4

Anti-Rad51D antibody [Rad51D 5B3/6] - ab20243 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone Rad51D 5B3/6

Anti-Rad51D antibody - C-terminal - ab136313 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RAD51L3 / RAD51D Antibody (Biotin) - LS-C140846 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RAD51L3 / RAD51D Antibody (aa2-15) - LS-C55355 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-RAD51L3 / RAD51D Antibody (DY488) - LS-C140848 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RAD51L3 / RAD51D Antibody (DY650) - LS-C140847 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RAD51L3 / RAD51D Antibody (DY550) - LS-C140850 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RAD51L3 / RAD51D Antibody (HRP) - LS-C140849 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RAD51L3 / RAD51D Antibody (clone 5B3/6, Biotin) - LS-C140856 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone 5B3/6

Anti-RAD51L3 / RAD51D Antibody (clone 5B3/6, DY650) - LS-C140857 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone 5B3/6

Anti-RAD51L3 / RAD51D Antibody (clone 5B3/6, DY488) - LS-C140858 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone 5B3/6

Anti-RAD51L3 / RAD51D Antibody (clone 5B3/6, HRP) - LS-C140859 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone 5B3/6

Anti-RAD51L3 / RAD51D Antibody (Ala152) - LS-C177138 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RAD51L3 / RAD51D Antibody (C-Terminus) - LS-C145404 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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