| Gene Symbol |
GRM8
|
| Entrez Gene |
2918
|
| Alt Symbol |
GLUR8, GPRC1H, MGLUR8, mGlu8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glutamate receptor, metabotropic 8
|
| Other Description |
metabotropic glutamate receptor 8
|
| Swissprots |
O95945 B0M0L0 B0FZ74 Q6J165 O15493 O00222 A4D0Y3 Q3MIV9 O95946 Q52M02
|
| Accessions |
AAB46348 ABY59657 CAJ46924 CBJ21208 EAL24322 EAW83621 EAW83622 EAW83623 EAW83624 O00222 AJ236921 CAB36968 AJ236922 CAB36969 AK123053 AK290197 BAF82886 AK315203 AY608335 AAT37959 BC093725 AAH93725 BC101675 AAI01676 BC143344 BG202742 BG211606 EU432125 ABY87924 U92459 AAB51764 U95025 AAB72040 XM_006715938 XP_006716001 XM_011516091 XP_011514393 XM_011516092 XP_011514394 XM_011516093 XP_011514395 XM_011516094 XP_011514396 XM_011516095 XP_011514397 XM_011516096 XP_011514398 XM_011516097 XP_011514399 XM_011516098 XP_011514400 XM_011516099 XP_011514401 XM_011516100 XP_011514402 XM_011516101 XP_011514403 XM_011516102 XP_011514404 XM_011516103 XP_011514405 XM_011516104 XP_011514406 XM_011516105 XP_011514407 XM_011516106 XP_011514408 XM_011516107 XP_011514409 XM_011516108 XP_011514410 XM_011516109 XP_011514411 NM_000845 NP_000836 NM_001127323 NP_001120795 NR_028041
|
| Function |
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:9473604}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Top Pathways |
Glutamatergic synapse, Neuroactive ligand-receptor interaction
|