WTIP

Gene Symbol	WTIP
Entrez Gene	126374
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	Wilms tumor 1 interacting protein
Other Description	WT1-interacting protein|Wilms tumor protein 1-interacting protein
Swissprots	A6NIX2
Accessions	A6NIX2 AK130059 BC030216 BC160027 AAI60027 XM_006723014 XP_006723077 XM_011526452 XP_011524754 XM_011526453 XP_011524755 NM_001080436 NP_001073905
Function	Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating chang
Subcellular Location	Cell junction, adherens junction. Nucleus {ECO:0000250}. Cytoplasm, P-body. Note=Following podocyte injury, caused by treatment with LPS, puromycin aminonucleoside, ultraviolet or hydrogen peroxide, translocates from sites of cell- cell contacts into the cytosol and nucleus. The shift from cell contacts to intracellular plaques starts as early as 1 hour after LPS stimulation and intranuclear localization begins 3 hours after LPS treatment. Maximal nuclear localization is achieved 6 hours after LPS treatment. Nuclear translocation requires dynein motor activity and intact microtubule network (By similarity). Returns to cell-cell contacts 24 hours after LPS stimulation. In the presence of ROR2, localizes to the plasma membrane (By similarity). {ECO:0000250}.
Top Pathways	Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

WTIP (D-12) - sc-241737 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

WTIP (S-13) - sc-241738 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

WTIP (T-12) - sc-241739 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-WTIP antibody - ab111392 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-WTIP antibody - ab169150 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-WTIP Antibody (aa474-503, AP) - LS-C273648 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WTIP Antibody (aa474-503, Biotin) - LS-C273650 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WTIP Antibody (aa474-503, APC) - LS-C273651 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WTIP Antibody (aa474-503, FITC) - LS-C273652 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WTIP Antibody (aa474-503, Azide-free, HRP) - LS-C273653 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WTIP Antibody (aa474-503, PE) - LS-C273654 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WTIP Antibody (aa474-503) - LS-C326377 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-WTIP Antibody (aa474-503) - LS-C160645 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

WTIP Antibody - H00126374-D01P from Novus Biologicals Prices $399.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

WTIP Antibody - H00126374-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

ANTI-WTIP (C-TERM) antibody produced in rabbit - SAB1301047 from Sigma-Aldrich Prices $326.50 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-WTIP antibody produced in rabbit - SAB1411766 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-WTIP antibody produced in mouse - SAB1411722 from Sigma-Aldrich Prices $347.00 Sizes 50 µg Host Mouse Clonality Polyclonal

WTIP-Antibody-C-term - AP11837b from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

WTIP Antibody - C-terminal region (OAAB08080) - OAAB08080 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

WTIP antibody - orb155428 from Biorbyt Prices $425.00 Sizes 100 μg Host Rabbit Clonality Polyclonal

WTIP Antibody - abx037394 from Abbexa Host Rabbit Clonality Polyclonal

WTIP (C-term) antibody - AP54573PU-N from Acris Antibodies Prices $330.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

WTIP antibody - H00126374-B01P from Acris Antibodies Prices $360.00 Sizes 50 µg Host Mouse Clonality Polyclonal

WTIP antibody - H00126374-D01P from Acris Antibodies Prices $390.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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