| Gene Symbol |
ZNF143
|
| Entrez Gene |
7702
|
| Alt Symbol |
SBF, STAF, pHZ-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger protein 143
|
| Other Description |
SPH-binding factor|hStaf|selenocysteine tRNA gene transcription-activating factor|transcriptional activator Staf
|
| Swissprots |
Q8WUK9 O75559 B4DLY5 P52747 A8K518 E7ER34
|
| Accessions |
CAC14172 CAC17610 EAW68589 P52747 AF071771 AAC96102 AK291133 BAF83822 AK297214 BAG59697 AK313330 AW162015 BC014458 BC020219 AAH20219 BF515092 BG825506 CN295530 EU446917 ABZ92446 XM_005253121 XP_005253178 XM_005253122 XP_005253179 XM_005253126 XP_005253183 XM_005253127 XP_005253184 XM_011520349 XP_011518651 NM_001282656 NP_001269585 NM_001282657 NP_001269586 NM_003442 NP_003433
|
| Function |
Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8. {ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:9776743}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Expressed in all tissues tested, with the strongest expression in ovary.
|
![Western Blot: ZNF143 Overexpression Lysate (Adult Normal) [NBL1-18062] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ZNF143.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7873_ZNF143%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-18062-img0002.jpg)