| Gene Symbol |
ISYNA1
|
| Entrez Gene |
51477
|
| Alt Symbol |
INO1, INOS, IPS, IPS 1, IPS-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
inositol-3-phosphate synthase 1
|
| Other Description |
MI-1-P synthase|MIP synthase|myo-inositol 1-phosphate synthase A1
|
| Swissprots |
Q9NSU0 Q9NVW7 Q9H2Y2 G5E9U0 Q7Z525 Q6NXT5 Q9BT65 Q9NPH2 B3KRT1
|
| Accessions |
AAF26739 EAW84703 EAW84704 EAW84705 EAW84706 Q9NPH2 AF086921 AAP97151 AF207640 AAG35698 AF220530 AAF26444 AI983065 AK001325 BAA91626 AK021526 BAB13837 AK092179 BAG52493 AK092433 AK093461 BAG52722 AK296022 BAH12239 AL137749 CAB70904 BC004320 AAH04320 BC018952 AAH18952 BC066902 AAH66902 BP392170 DA615868 DB056699 DB244754 DC371373 DQ893465 ABM84391 DQ896336 ABM87335 XM_011528059 XP_011526361 NM_001170938 NP_001164409 NM_001253389 NP_001240318 NM_016368 NP_057452 NR_045573 NR_045574 NM_001170939
|
| Function |
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds. {ECO:0000269|PubMed:15024000}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in testis, ovary, heart, placenta and pancreas. Weakly expressed in blood leukocyte, thymus, skeletal muscle and colon. {ECO:0000269|PubMed:12941308}.
|
| Top Pathways |
Inositol phosphate metabolism
|
![Western Blot: ISYNA1 Overexpression Lysate (Adult Normal) [NBP2-07041] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ISYNA1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4790_ISYNA1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07041-img0001.jpg)