| Gene Symbol |
WNT5A
|
| Entrez Gene |
7474
|
| Alt Symbol |
hWNT5A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
wingless-type MMTV integration site family, member 5A
|
| Other Description |
WNT-5A protein|protein Wnt-5a
|
| Swissprots |
Q6P278 P41221 A8K4A4
|
| Accessions |
CAI38645 CAY02596 CAY86018 EAW65310 EAW65311 P41221 AI634753 AK021503 AK090582 BAG52191 AK290375 BAF83064 AK290869 BAF83558 AU118341 BC064694 AAH64694 BC074783 AAH74783 BF218039 BM728706 BU742635 DB224740 EF028086 ABK20872 HG495695 JF432410 ADZ15627 L20861 AAA16842 XM_006713324 XP_006713387 XM_011534081 XP_011532383 XM_011534082 XP_011532384 XM_011534083 XP_011532385 XM_011534084 XP_011532386 XM_011534085 XP_011532387 XM_011534086 XP_011532388 XM_011534087 XP_011532389 XM_011534088 XP_011532390 XM_011534089 XP_011532391 NM_001256105 NP_001243034 NM_003392 NP_003383
|
| Function |
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes. {ECO:0000269|PubMed:15735754, ECO:0000269|PubMed:17426020}.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix.
|
| Tissue Specificity |
Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level). {ECO:0000269|PubMed:15735754}.
|
| Top Pathways |
Proteoglycans in cancer, Wnt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Hippo signaling pathway, HTLV-I infection
|